ArticleFrontiers in oncology2026
Venetoclax combined with azacitidine in the treatment of secondary myelodysplastic syndrome following multiple myeloma: a case report and literature review.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
We conducted a retrospective analysis of the clinical data of a patient with myelodysplastic syndrome (MDS) secondary to stable multiple myeloma (MM), who was treated with a combination of venetoclax and azacitidine at the Fifth People's Hospital of Chengdu. Additionally, we reviewed the relevant literature. The patient, a 74-year-old male, was initially diagnosed with multiple myeloma (IgA-γ, DS IIIA, ISS III, R-ISS II) and achieved a very good partial response (VGPR) following sequential treatments with BCTD, RVD, and PVD regimens, subsequently receiving maintenance therapy with pomalidomide. Despite being in continuous remission, the patient developed secondary myelodysplastic syndrome characterized by refractory anemia with excess blasts-2 (MDS-RAEB-II) 51 months post-initial MM diagnosis. He was then treated with venetoclax in combination with azacitidine. After the first treatment course, the patient achieved morphological partial remission of MDS. However, due to non-adherence to continuous treatment, he ultimately succumbed to a secondary infection.
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