ArticleActa Cardiologica Sinica2026
High-Density Lipoprotein Treatment Effectively Protected the Endothelial Cells, Mitochondria and Myocardium Against Oxidized Low-Density Lipoprotein Damage.
Article in Acta Cardiologica Sinica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Background: This study evaluated whether high-density lipoprotein (HDL) treatment, shown to preserve endothelial cell integrity, could protect the left ventricular ejection fraction (LVEF) in rats from ischemia-reperfusion (IR) injury. Methods: Human umbilical vein endothelial cells (HUVECs) were assigned to six groups: G1 (HUVECs alone); G2 (+healthy-derived oxidized LDL [ox-LDL Results: In vitro, protein and cellular markers of apoptosis, oxidative stress, mitochondrial damage, and MAPK-family signaling were lowest in G1, highest in G4, and significantly lower in G3 than in G2, G5, and G6 (all p < 0.0001); antioxidants and angiogenesis showed the opposite pattern. By day 28, LVEF and LV fractional shortening were highest in Group 1, lowest in Group 5, higher in Group 4 than in Groups 2, 3, and 6, and higher in Group 6 than in Groups 2 and 3 (all p < 0.0001). Inflammation, MAPK cascades, oxidative stress, mitochondrial damage, and LV infarct/fibrotic areas followed the inverse pattern, while antioxidants paralleled LVEF. Conclusions: HDL
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