Adolescent social isolation promotes oxycodone consumption and augments mu opioid receptor responsiveness in the ventral pallidum.

Gavin J Vaughan, Hetvi Trivedi, Skylee M Eiffert, Molly M Deak, Anushree N Karkhanis

Abstract read

In one paragraph

Article in Addiction neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Gavin J VaughanDepartment of Psychology, Center for Developmental and Behavioral Neuroscience, Binghamton University - The State University of New York, Binghamton, NY, USA.

Hetvi TrivediDepartment of Psychology, Center for Developmental and Behavioral Neuroscience, Binghamton University - The State University of New York, Binghamton, NY, USA.

Skylee M EiffertDepartment of Psychology, Center for Developmental and Behavioral Neuroscience, Binghamton University - The State University of New York, Binghamton, NY, USA.

Molly M DeakDepartment of Psychology, Center for Developmental and Behavioral Neuroscience, Binghamton University - The State University of New York, Binghamton, NY, USA.

Anushree N KarkhanisDepartment of Psychology, Center for Developmental and Behavioral Neuroscience, Binghamton University - The State University of New York, Binghamton, NY, USA.

Funding

Impact of early life stress on accumbal kappa opioid signaling and ethanol intakeK01AA023874 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KARKHANIS, ANUSHREE N · 2016 to 2020

$673k

NIAAA NIH HHS K01 AA023874

6 · The paper itself

Abstract

Exposure to adversity during adolescence augments vulnerability to opioid use disorders in adulthood, yet the neurobiological mechanisms underlying this risk remain incompletely understood. The ventral pallidum (VP) is a region highly implicated in reward valuation and is sensitive to both stress and opioid modulation. Here, we examined whether adolescent social isolation (aSI) alters consumption of oxycodone and mu-opioid receptor (MOR) mediated inhibition of dopamine release in the VP. Male and female rats were exposed to aSI or group housing during adolescence (aGH) and assessed in adulthood for oxycodone consumption and pallidal dopamine release using

Indexed as

Adolescent stressdopaminemu-opioid receptoroxycodoneventral pallidum

Identifiers

PMID42524232

DOI10.1016/j.addicn.2026.100267

PMCPMC13410844

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.