Evidence map›Paper›PMID 42524288›Full record

ArticleAging and health research2026

Efficacy of sequential aerobic exercise and cognitive training in older adults with amnestic mild cognitive impairment.

Fang Yu, Dereck L Salisbury, Michael Todd, Lisa S Chow, Anton P Porsteinsson, Molly Maxfield, Rodney P Joseph, Frank LoVecchio, Kathi L Heffner, F Vankee Lin

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging and health research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03313895 (Efficacy and Mechanisms of Combined Aerobic Exercise and Cognitive Training), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03313895 nacompletednot on this map

Efficacy and Mechanisms of Combined Aerobic Exercise and Cognitive Training (ACT) in MCI

TypeinterventionalSponsorArizona State UniversityRan2018 to 2024Enrolled146ConditionsMild Cognitive ImpairmentArmsAerobic & Cognitive Training (ACT), Cycling Only, Cognitive Training Only, Stretching and Mental Stimulating Activities
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fang YuArizona State University Edson College of Nursing and Health Innovation.ORCID 0000-0002-9399-1987
Dereck L SalisburyUniversity of Minnesota School of Nursing.
Michael ToddArizona State University Edson College of Nursing and Health Innovation.
Lisa S ChowUniversity of Minnesota School of Medicine.ORCID 0000-0002-6210-2307
Anton P PorsteinssonUniversity of Rochester Medical Center.ORCID 0000-0002-0166-1738
Molly MaxfieldArizona State University Edson College of Nursing and Health Innovation.
Rodney P JosephArizona State University Edson College of Nursing and Health Innovation.
Frank LoVecchioArizona State University Clinical Research Services.
Kathi L HeffnerUniversity of Rochester School of Nursing.
F Vankee LinStanford University Department of Psychiatry and Behavioral Sciences.

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
Efficacy and Mechanisms of Combined Aerobic Exercise and Cognitive Training in MCI_The ACT Trial COVID Admin SupR01AG055469 · NIA · UNIVERSITY OF MINNESOTA · PI LIN, FENG VANKEE, YU, FANG · 2017 to 2023
$4.4M
NCATS NIH HHS UL1 TR000114NIA NIH HHS R01 AG055469
6 · The paper itself

Abstract

Background: Multi-component interventions may be critical for reducing Alzheimer's disease (AD) risk since AD pathogenesis is multi-factorial. Combined Aerobic exercise and Cognitive Training (ACT) may have synergistic effects, but studies are limited with mixed findings. Methods: A 3-site, single-blinded Stage II 2 × 2 factorial trial aimed to test the effects of 6-month ACT on cognition in older adults with amnestic mild cognitive impairment in academic research facilities and gyms. Among 325 participants consented, 146 were enrolled and randomized equally to 6-month ACT, cycling only, speed of processing (SOP) cognitive training only, or control. Primary outcomes, executive function and episodic memory, were measured with alternating EXAMINER and Brief Visuospatial Memory Test-Revised (BVMT-R) forms at baseline, 3, 6, 12, and 18 months, and global cognition with the Montreal Cognitive Assessment (MoCA) and EXAMINER/BVMT-R composite. Results: Executive function improved significantly from baseline to 6 months ( Conclusions: ACT's synergistic effects remain to be determined. All interventions are feasible for clinical practice. Trial Registration: www.clinicaltrials.gov (NCT03313895; date of registration: 10/18/2017).

Indexed as

Aerobic exerciseAlzheimer’s diseaseCognitive trainingExecutive functionMemory

Identifiers

PMID42524288
PMCPMC13410703

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.