Evidence map›Paper›PMID 42524394›Full record

ArticleFrontiers in surgery2026

Nonlinear relationship and threshold effect of D-dimer on preoperative deep vein thrombosis in patients with ankle fractures: a retrospective study.

Zi-Ruo Zhang, Pei-Pei Li, Dan Chen, Si Gao, Xing Fan, Hong-Mou Zhao, Jing Hu, Jin Tong, Hong Zhi

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Article in Frontiers in surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Zi-Ruo Zhang *Foot and Ankle Orthopedic Diagnosis and Treatment Center, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Pei-Pei Li *General Medical Ward, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Dan Chen *Foot and Ankle Orthopedic Diagnosis and Treatment Center, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Si GaoFoot and Ankle Orthopedic Diagnosis and Treatment Center, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Xing FanFoot and Ankle Orthopedic Diagnosis and Treatment Center, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Hong-Mou ZhaoFoot and Ankle Orthopedic Diagnosis and Treatment Center, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Jing HuAcademic Development Department, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Jin TongFoot and Ankle Orthopedic Diagnosis and Treatment Center, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Hong ZhiDepartment of Nursing, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The purpose of this study is to explore the association between D-dimer levels and the likelihood of preoperative deep vein thrombosis (DVT) in patients with ankle fractures. Methods: This retrospective study included ankle fracture patients admitted to Xi'an Honghui Hospital's Foot and Ankle Surgery Center from January 2024 to November 2025. Preoperative DVT was identified using Doppler ultrasound, and the relationship between D-dimer levels and DVT was analyzed using multivariate logistic regression and generalized additive models. Results: Among 818 patients, 13.45% developed preoperative DVT. D-dimer was an independent risk factor of preoperative DVT (OR = 1.14, 95% CI: 1.03-1.26, Conclusion: D-dimer is independently associated with preoperative DVT in ankle fracture patients, and the relationship appears to be non-linear.

Indexed as

ankle fractureD-dimerdeep vein thrombosisnon-linear relationshipretrospective study

Identifiers

PMID42524394
PMCPMC13412180

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.