ArticleInternational journal of general medicine2026
Relationship of Estimated Glomerular Filtration Rate (eGFR) and Neuron-Specific Enolase (NSE) with Cognitive Dysfunction in Type 2 Diabetes Mellitus: A Cross-Sectional Analysis.
Article in International journal of general medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Diabetic encephalopathy is a common complication of type 2 diabetes mellitus (T2DM) and a major cause of cognitive dysfunction. The kidneys and the brain share several similar physiological characteristics, which may render them susceptible to analogous pathological processes. Estimated glomerular filtration rate (eGFR) is a widely used indicator of kidney function and may reflect systemic microvascular injury, impaired renal function accelerates cerebral microangiopathy and exacerbates cognitive deterioration. Neuron-specific enolase (NSE) is a well-recognized neuronal injury biomarker, It is a glycolytic rate-limiting enzyme abundant in cerebral neuron cytoplasm, leaks into blood or cerebrospinal fluid upon neuronal membrane damage following central nervous system injury. Existing studies separately explored renal function or neuronal injury indicators in diabetic cognitive dysfunction, while few studies combined eGFR and NSE to jointly predict cognitive dysfunction in T2DM populations, lacking combined diagnostic evidence of kidney-brain damage markers. Purpose: This study aimed to investigate the associations of eGFR and NSE with cognitive function in T2DM patients and evaluate their predictive value for cognitive dysfunction. Methods: This cross-sectional study retrospectively enrolled 80 Results: Compared with the DNCD group, the DCD group had significantly lower eGFR and higher NSE, HbA1c, and Hcy levels (all Conclusion: Elevated NSE, HbA1c, and Hcy are independently negatively associated with cognitive function, while eGFR was independently positively associated with cognitive function in
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