Evidence map›Paper›PMID 42524498›Full record

ArticleInternational journal of biological sciences2026

SYNCRIP drives ferroptosis resistance and metabolic activation via SIRT1 and HK2 in glioblastoma.

Hyeon Ji Kim, Hyo-Jin Song, Yu Gyung Kim, Mingyu Kang, Tae-Jun Kim, Jin-Seok Byun, Do-Yeon Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hyeon Ji KimDepartment of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, Republic of Korea.
Hyo-Jin SongDepartment of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, Republic of Korea.
Yu Gyung KimDepartment of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, Republic of Korea.
Mingyu KangDivision of Cancer Biology, Research Institute, National Cancer Center, Goyang 10408, Gyeonggi-do, Republic of Korea.
Tae-Jun KimDivision of Radiation Biomedical Research, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Republic of Korea.
Jin-Seok ByunDepartment of Oral Medicine, School of Dentistry, Kyungpook National University, Daegu 41940, Republic of Korea.
Do-Yeon KimDepartment of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synaptotagmin-binding cytoplasmic RNA-interacting protein (SYNCRIP) is an RNA-binding protein (RBP) implicated in the pathogenesis of various cancers through involvement in regulating multiple cellular processes. Notably, this study identified that SYNCRIP expression is significantly elevated in glioblastoma (GBM) and is associated with poor prognosis and tumor progression. Mechanistically, SYNCRIP upregulates SIRT1 expression at both the transcriptional and post-transcriptional levels by stabilizing

Indexed as

FerroptosisGlioblastomaHexokinaseRNA-Binding ProteinsSirtuin 1Brain NeoplasmsCell Line, TumorEpithelial-Mesenchymal TransitionGene Expression Regulation, NeoplasticHumansReactive Oxygen SpeciesHexokinaseHK2 protein, humanReactive Oxygen SpeciesRNA-Binding ProteinsSIRT1 protein, humanSirtuin 1ferroptosisHK2IRESSIRT1SYNCRIPtranscription

Identifiers

PMID42524498
PMCPMC13412200

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.