Evidence map›Paper›PMID 42524609›Full record

ReviewInternational journal of biological sciences2026

Leonardo Martin, Jure Bohinc, Alessandra Recchia, Stefano Gritti, Giorgia Santilli, Joanna Zeyland, Melita Vidaković, Nevena Grdović, Karim Benabdellah, María Ortiz-Bueno and 19 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Leonardo MartinDepartment of Pharmaceutical Sciences, Laboratory of Physiopharmacology, University of Antwerp, Belgium.
Jure BohincDepartment of Synthetic Biology and Immunology, National Institute of Chemistry, Ljubljana, Slovenia.
Alessandra RecchiaDepartment of Life Sciences, University of Modena and Reggio Emilia, Modena and Reggio Emilia, Emilia-Romagna, Italy.
Stefano GrittiInfection, Immunity and Inflammation Research and Teaching Department, University College London Great Ormond Street Institute of Child Health, London, United Kingdom.
Giorgia SantilliInfection, Immunity and Inflammation Research and Teaching Department, University College London Great Ormond Street Institute of Child Health, London, United Kingdom.
Joanna ZeylandDepartment of Biochemistry and Biotechnology, University of Life Sciences in Poznań, Poland.
Melita VidakovićInstitute for Biological Research Sinisa Stankovic, National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia.
Nevena GrdovićInstitute for Biological Research Sinisa Stankovic, National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia.
Karim BenabdellahDepartment of Genomic Medicine, Andalusian Regional Government Centre for Genomics and Oncological Research (GENYO), Pfizer-University of Granada, Granada, Spain.
María Ortiz-BuenoDepartment of Genomic Medicine, Andalusian Regional Government Centre for Genomics and Oncological Research (GENYO), Pfizer-University of Granada, Granada, Spain.
Bilge Debelec ButunerDept. of Pharmaceutical Biotechnology, Faculty of Pharmacy, Ege University, Izmir, Turkey.
Luana PisanielloDepartment of Physiological Sciences, Santa Casa de São Paulo School of Medical Sciences, São Paulo, Brazil.
Roberta StilhanoDepartment of Physiological Sciences, Santa Casa de São Paulo School of Medical Sciences, São Paulo, Brazil.
Daniela BenatiDepartment of Life Sciences, University of Modena and Reggio Emilia, Modena and Reggio Emilia, Emilia-Romagna, Italy.
Fatma Zehra HapilDepartment of Medical Biology and Genetics, Akdeniz University School of Medicine, Antalya, Turkey.
Shariqa KhawajaCentre for Regenerative Medicine and Stem Cell Research, Aga Khan University, Karachi, Pakistan.
Rajeevkumar Raveendran NairKavli Institute for Systems Neuroscience, Faculty of Medicine, NTNU, Trondheim, Norway.
Carla GiacomelliUniversidad Nacional de Córdoba, Facultad de Ciencias Químicas, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones en Fisicoquímica de Córdoba, Argentina.
Erden AtillaDepartment of Genomic Medicine, Andalusian Regional Government Centre for Genomics and Oncological Research (GENYO), Pfizer-University of Granada, Granada, Spain.
Federica ZinghirinoDepartment of Biochemical Engineering, University College London (UCL), London, United Kingdom.
Tommaso FerrariDepartment of Life Sciences, University of Modena and Reggio Emilia, Modena and Reggio Emilia, Emilia-Romagna, Italy.
Federico CorradiDepartment of Life Sciences, University of Modena and Reggio Emilia, Modena and Reggio Emilia, Emilia-Romagna, Italy.
Tamas J LauferDepartment of Biochemical Engineering, University College London (UCL), London, United Kingdom.
Denis KhnykinDepartment of Pathology, Oslo University Hospital, Oslo, Norway.
Gloria González AseguinolazaDNA & RNA Medicine Division, CIMA, University of Navarra, IdisNA, Pamplona, Navarra, Spain.
Mojca SkrbinekDepartment of Synthetic Biology and Immunology, National Institute of Chemistry, Ljubljana, Slovenia.
Tjaša MlakarDepartment of Synthetic Biology and Immunology, National Institute of Chemistry, Ljubljana, Slovenia.
Tjaša LapanjaCentre for Technologies of Gene and Cell Therapy, National Institute of Chemistry, Ljubljana, Slovenia.
Duško LainščekDepartment of Synthetic Biology and Immunology, National Institute of Chemistry, Ljubljana, Slovenia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CRISPR-based genome and epigenome editing technologies have rapidly evolved from programmable nucleases into a diverse therapeutic toolbox encompassing conventional CRISPR systems, base editing, prime editing, RNA targeting, and epigenetic modulation. While early clinical successes relied on

Indexed as

CRISPR-Cas SystemsGene EditingGene Transfer TechniquesAnimalsEpigenome EditingGenetic TherapyHumansbase editingCRISPR delivery systemsin vivo genome editinglipid nanoparticlesorgan-specific gene therapyprime editingviral vectors

Identifiers

PMID42524609
PMCPMC13412194

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.