Evidence map›Paper›PMID 42524682›Full record

ArticleLiver cancer2026

Dissecting the Transcriptomic Profile of CD163

Camilla De Carlo, Anna Rita Putignano, Reha Akpinar, Barbara Durante, Marika Viatore, Rebecca Polidori, Cristiana Soldani, Barbara Franceschini, Gianluca Basso, Fabio Procopio and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Liver cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Camilla De CarloDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
Anna Rita PutignanoDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
Reha AkpinarDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
Barbara DuranteDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
Marika ViatoreDepartment of Immunology and Inflammation, IRCCS Humanitas Research Hospital, Rozzano, Italy.
Rebecca PolidoriDepartment of Immunology and Inflammation, IRCCS Humanitas Research Hospital, Rozzano, Italy.
Cristiana SoldaniLaboratory of Hepatobiliary Immunopathology, IRCCS Humanitas Research Hospital, Rozzano, Italy.
Barbara FranceschiniLaboratory of Hepatobiliary Immunopathology, IRCCS Humanitas Research Hospital, Rozzano, Italy.
Gianluca BassoTranslational Genomic Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
Fabio ProcopioDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
Guido CostaDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
Fabio GrizziDepartment of Immunology and Inflammation, IRCCS Humanitas Research Hospital, Rozzano, Italy.
Luigi Maria TerraccianoDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
Guido TorzilliDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
Lorenza RimassaDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
Ana LleoDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
Salvatore PiscuoglioDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
Charlotte K Y NgDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
Erica VillaGastroenterology Unit, CHIMOMO Department, University of Modena and Reggio Emilia, Modena, Italy.
Sergio MarchiniTranslational Genomic Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
Federica MarchesiDepartment of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy.
Luca Di TommasoDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Hepatocellular carcinoma (HCC) is characterized by a highly vascularized tumor microenvironment (TME), with VETC being a distinctive, frequent, and prognostically unfavorable type of this vascular TME. VETC Methods: A total of 7 resected HCCs were retrospectively analyzed according to VETC status. Spatial transcriptomic profiling was performed on formalin-fixed, paraffin-embedded samples using NanoString GeoMx™ DSP, followed by differential expression and pathway analyses. SPP1 expression was further evaluated by immunohistochemistry and multiplex immunofluorescence. Results: This study aimed to characterize these macrophages with a spatial transcriptomic approach. We demonstrated that they exhibit a pro-tumor, M2-like tumor-associated macrophages (TAMs) signature (SPP1, ACP5, GPNMB, and FABP5), distinct from those in VETC Conclusion: Our findings suggest that M2-like TAMs in VETC

Indexed as

Hepatocellular carcinomaMacrophagesMicroenvironmentVessel that encapsulate tumor cluster

Identifiers

PMID42524682
PMCPMC13412412

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.