Evidence map›Paper›PMID 42524684›Full record

ArticleCureus2026

Treatment-Induced Neuropathy of Diabetes: Focus on Autonomic Neuropathy.

Benjamin MacIsaac, Richard MacIsaac, Lai Yin Law

Abstract readCase Reports
In one paragraph

Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Benjamin MacIsaacDepartment of General Medicine, St Vincent's Hospital, Melbourne, AUS.
Richard MacIsaacDepartment of Endocrinology and Diabetes, St Vincent's Hospital, Melbourne, AUS.
Lai Yin LawDepartment of Neurology, St Vincent's Hospital, Melbourne, AUS.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Treatment-induced neuropathy of diabetes (TIND) is characterised by the acute onset of peripheral and autonomic neuropathy following rapid correction of chronic hyperglycaemia. We present a case of TIND presenting with severe, treatment-resistant postural hypotension, with a quantitative sudomotor axon reflex test confirming autonomic small fibre neuropathy. This complication is under-recognised compared to early worsening of diabetic retinopathy or peripheral neuropathy but causes significant patient morbidity. Given the limited treatment options once symptoms develop, prevention is critical. Future research should aim to validate gradual HbA1c reduction as an effective preventative strategy and focus on developing targeted treatment options for TIND, especially its autonomic manifestations.

Indexed as

autonomic nervous system diseaseautonomic neuropathydiabetesdiabetic neuropathyinsulinneuropathytreatment-induced neuropathy of diabetestreatment neuropathy

Identifiers

PMID42524684
PMCPMC13412893

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.