Evidence map›Paper›PMID 42525447›Full record

ArticleMicrobial genomics2026

Benchmarking of real-time, field-deployable whole-genome sequencing of

Zahra Razook, Somya Mehra, Myo T Naung, Brittany Gilchrist, Sachintha Wijegunasekara, Digjaya Utama, Dulcie Lautu-Gumal, Abebe A Fola, Didier Menard, James Kazura and 5 more

Abstract read
In one paragraph

Article in Microbial genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Unpacking boxes: identification of novel inhibitors of malaria parasite invasion.International journal for parasitology. Drugs and drug resistance · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Nanopore sequencing in veterinary medicine: from concepts to clinical applications.Frontiers in cellular and infection microbiology · 2025
    Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Zahra RazookPopulation Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Somya MehraPopulation Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Myo T NaungPopulation Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Brittany GilchristPopulation Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Sachintha WijegunasekaraLife Sciences Discipline, Burnet Institute, Melbourne, Victoria, Australia.
Digjaya UtamaPopulation Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Dulcie Lautu-GumalPopulation Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Abebe A FolaPopulation Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Didier MenardDepartment of Parasites and Insect Vectors, Institut Pasteur Paris, Paris, France.
James KazuraDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, USA.
Moses LamanVector Borne Diseases Unit, Papua New Guinea Institute of Medical Research, Madang, Madang Province, Papua New Guinea.
Ivo MuellerPopulation Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Leanne J RobinsonPopulation Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Melanie BahloPopulation Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Alyssa E BarryPopulation Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.

Funding

TransmissionU19AI089686 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI KAZURA, JAMES WALTER · 2010 to 2016
$9.9M
Understanding, tracking and eliminating malaria transmission in the Asia - Pacific RegionU19AI129392 · NIAID · WALTER AND ELIZA HALL INST MEDICAL RES · PI Ivo J Mueller · 2017 to 2026
$7.1M
NIAID NIH HHS U19 AI089686NIAID NIH HHS U19 AI129392
6 · The paper itself

Abstract

Malaria parasite genomes have been generated predominantly using Illumina short-read sequencing that requires expensive equipment, is time-consuming with complex protocols, and does not adequately interrogate complex genomic regions that harbour important malaria virulence determinants. The portable Oxford Nanopore Technologies MinION platform generates long reads in real time and may overcome these limitations. We present compelling evidence that Nanopore sequencing delivers valuable additional information for malaria parasites with similar data fidelity for single nucleotide variant (SNV) calls compared to standard Illumina whole-genome sequencing. We demonstrate this through sequencing of pure

Indexed as

Genome, ProtozoanNanopore SequencingPlasmodium falciparumWhole Genome SequencingHigh-Throughput Nucleotide SequencingHumansMalaria, FalciparumNanoporesPolymorphism, Single NucleotideSequence Analysis, DNAdrug resistancegenomicslong readmalariaNanoporePlasmodium falciparumstructural variants

Identifiers

PMID42525447
PMCPMC13435551

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.