Evidence map›Paper›PMID 42525548›Full record

ArticleeLife2026

Acute opioid responses are modulated by dynamic interactions of

Paige M Lemen, Yanning Zuo, Alexander S Hatoum, Price E Dickson, Guy Mittleman, Arpana Agrawal, Benjamin C Reiner, Wade Berrettini, David George Ashbrook, Mustafa Hakan Gunturkun and 7 more

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Paige M LemenUniversity of Tennessee Health Science Center, Memphis, United States.ORCID https://orcid.org/0000-0002-1774-0385
Yanning ZuoUniversity of California, San Diego, San Diego, United States.
Alexander S HatoumWashington University School of Medicine, St. Louis, United States.ORCID https://orcid.org/0000-0002-8002-7267
Price E DicksonMarshall University, Huntington, United States.
Guy MittlemanBall State University, Muncie, United States.
Arpana AgrawalWashington University School of Medicine, St. Louis, United States.
Benjamin C ReinerUniversity of Pennsylvania, Philadelphia, United States.
Wade BerrettiniUniversity of Pennsylvania, Philadelphia, United States.
David George AshbrookUniversity of Tennessee Health Science Center, Memphis, United States.ORCID https://orcid.org/0000-0002-7397-8910
Mustafa Hakan GunturkunUniversity of Tennessee Health Science Center, Memphis, United States.
Xusheng WangUniversity of Tennessee Health Science Center, Memphis, United States.
Megan K MulliganUniversity of Tennessee Health Science Center, Memphis, United States.
Caleb J BrownNash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, United States.
Eric J NestlerNash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, United States.ORCID https://orcid.org/0000-0002-7905-2000
Francesca TeleseUniversity of California, San Diego, San Diego, United States.
Robert W WilliamsUniversity of Tennessee Health Science Center, Memphis, United States.ORCID https://orcid.org/0000-0001-8924-4447
Hao ChenUniversity of Tennessee Health Science Center, Memphis, United States.ORCID https://orcid.org/0000-0002-2680-6921

Funding

Genetics of oxycodone intake in a hybrid rat diversity panel.U01DA053672 · NIDA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI CHEN, HAO, SHARP, BURT M · 2021 to 2025
$3.4M
National Institute of Development Administration U01DA053672NIDA NIH HHS U01 DA053672
6 · The paper itself

Abstract

We generated time-series data for 105 morphine- and naloxone-related traits across ~700 BXD mice (64 diverse strains for both sexes) for 3 hr after a single morphine injection. Variations in responses were mapped using genome sequencing-based genotypes. The locomotor responses to morphine mapped to the µ opioid receptor gene (

Indexed as

Analgesics, OpioidMorphineReceptors, Opioid, muAnimalsEpistasis, GeneticFemaleLocomotionMaleMiceMice, Inbred C57BLNaloxoneRatsAnalgesics, OpioidMorphineNaloxoneOprm protein, mouseReceptors, Opioid, muepistasisFgf12geneticsgenomicshumanlocomotionmouseneuroscienceOprm1QTLquantitative trait locirat

Identifiers

PMID42525548
PMCPMC13421559

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.