Evidence map›Paper›PMID 42525742›Full record

ArticleScience advances2026

Lipidomic profiling reveals age-dependent changes in plasma membrane lipids that affect neural stem cell aging.

Xiaoai Zhao, Ryan M Feitzinger, Jeeyoon Na, Xin Yan, Andrew Erickson, Kévin Contrepois, Olivia Y Zhou, Francesco Vallania, Mathew Ellenberger, Chloe M Kashiwagi and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Xiaoai ZhaoDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID 0000-0001-6602-0838
Ryan M FeitzingerDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID 0000-0002-5990-3357
Jeeyoon NaDepartment of Genetics, Stanford University, Stanford, CA, USA.
Xin YanDepartment of Chemistry, Stanford University, Stanford, CA, USA.
Andrew EricksonDepartment of Comparative Medicine, Yale University, New Haven, CT, USA.
Kévin ContrepoisDepartment of Genetics, Stanford University, Stanford, CA, USA.
Olivia Y ZhouDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID 0000-0003-2107-2567
Francesco VallaniaInstitute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.ORCID 0000-0003-0098-249X
Mathew EllenbergerDepartment of Genetics, Stanford University, Stanford, CA, USA.
Chloe M KashiwagiDepartment of Genetics, Stanford University, Stanford, CA, USA.
Stephanie D GagnonDepartment of Genetics, Stanford University, Stanford, CA, USA.
Cynthia J SiebrandDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID 0000-0001-5422-1835
Matias CabrujaDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID 0000-0001-7691-6494
Gavin M TraberDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID 0000-0003-3494-9196
Andrew McKayDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID 0000-0002-9179-5018
Daniel HornburgDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID 0000-0002-6618-7774
Purvesh KhatriInstitute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.ORCID 0000-0002-4143-4708
Michael P SnyderDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID 0000-0003-0784-7987
Richard N ZareDepartment of Chemistry, Stanford University, Stanford, CA, USA.ORCID 0000-0001-5266-4253
Anne BrunetDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID 0000-0002-4608-6845

Funding

Using a tonsil organoid system to probe conditions for the induction of protective antibody and T cell responses to influenza.U19AI057229 · NIAID · STANFORD UNIVERSITY · PI Mark Morris Davis · 2003 to 2026
$88.5M
Wnt signaling in muscle stem cell agingP01AG036695 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MARGARET A. GOODELL · 2011 to 2026
$29.3M
Systems biological assessment of T cell responses to vaccinationU19AI167903 · NIAID · STANFORD UNIVERSITY · PI BALI PULENDRAN · 2022 to 2026
$13.2M
NIAID NIH HHS U19 AI057229NIAID NIH HHS U19 AI167903NIA NIH HHS P01 AG036695
6 · The paper itself

Abstract

The aging brain exhibits a decline in the regenerative populations of neural stem cells (NSCs). While mechanisms that restore old NSC function have started to be identified, the role of lipids-especially complex lipids-in NSC aging remains largely unclear. Using lipidomic profiling by mass spectrometry, we identify age-related changes in complex lipids in quiescent NSCs in vitro and in vivo. Moreover, several polyunsaturated fatty acids increase across lipid classes in quiescent NSCs during aging. Using spatial lipidomics, we find that some of the changes in complex lipids are also observed in situ. Several age-related changes in complex lipids and side chain composition are occurring at the plasma membrane, as revealed by lipidomic profiling of isolated plasma membrane vesicles. Experimentally, we show that aging is accompanied by a decrease in plasma membrane order, a key membrane biophysical property, in old quiescent NSCs in vitro and in vivo. To determine the functional role of plasma membrane lipids in aging NSCs, we performed genetic and supplementation studies. Knocking out the phospholipid acyltransferase MBOAT2 exacerbates age-related lipidomic changes in old quiescent NSCs and impedes their ability to activate.

Indexed as

AgingCell MembraneCellular SenescenceLipidomicsMembrane LipidsNeural Stem CellsAnimalsMiceMembrane Lipids

Identifiers

PMID42525742
PMCPMC13418745

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.