In one paragraphArticle in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
16 authors.
Alisha DhimanBorch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0002-4395-9292 Mitchell G AyersBorch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0003-4049-9013 Guanming JiaoBorch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA.
Aparna B ShindeBorch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0002-0822-1313 Saeed Salehin AkhandBorch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA.
Marco HadisuryaDepartment of Biochemistry, Purdue University, West Lafayette, IN 47907, USA.
Elizabeth G PorterBorch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA.
W Andy TaoBorch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0002-5535-5517 Yucheng ZhangRosen Center for Advanced Computing (RCAC), Purdue University, West Lafayette, IN 47907, USA.
Sagar M UtturkarPurdue Institute for Cancer Research Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0002-3453-1948 Michael K WendtPurdue Institute for Cancer Research Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0002-3665-7413 Emily C DykhuizenBorch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0003-3072-1469 Funding
Tumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI David W Clapp · 1999 to 2026
$59.3MTransgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI John Tesmer · 1985 to 2026
$43.4MIndiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3MEngineering the Premetastatic NicheR01CA281216 · NCI · PURDUE UNIVERSITY · PI Luis Solorio, Michael Keith Wendt · 2024 to 2026
$2.6MHigh-throughput methyltransferase assays using recombinant nucleosome substratesR44GM117683 · NIGMS · EPICYPHER, INC. · PI SUN, ZU-WEN · 2018 to 2019
$1.7MThe tumor suppressive role of PBRM1, the bromodomain-containing subunit of the PBAF chromatin remodeling complexU01CA207532 · NCI · PURDUE UNIVERSITY · PI DYKHUIZEN, EMILY CARLA · 2017 to 2021
$1.7MBarcoded nucleosomes for analyzing combinatorial epigenetic regulatorsR44GM116584 · NIGMS · EPICYPHER, INC. · PI SUN, ZU-WEN · 2017 to 2018
$1.6MChromatin connects metabolism to circadian gene regulation in the aging eyeR01EY033734 · NEI · PURDUE UNIVERSITY · PI Vikki Marie Weake · 2023 to 2026
$1.5MNCATS NIH HHS UL1 TR001108NCI NIH HHS P30 CA023168NCI NIH HHS P30 CA082709NCI NIH HHS R01 CA281216NCI NIH HHS U01 CA207532NEI NIH HHS R01 EY033734NIGMS NIH HHS R44 GM116584NIGMS NIH HHS R44 GM117683
6 · The paper itselfAbstract
SWI/SNF chromatin remodelers are represented by three biochemically distinct subcomplexes, the abundant cBAF and the less abundant PBAF and GBAF. Genetics have identified important roles for PBAF in development and disease; however, relating PBAF-mediated phenotypes to biochemical function in chromatin regulation and gene activation has been challenging. Here, we show that the PBRM1 subunit of PBAF is critical for the completion of TGFβ1-mediated epithelial-mesenchymal transition (EMT) of mammary cells in vitro as well as the metastasis of murine breast cancers in vivo. Using epigenomics to profile different stages of EMT, we find that PBRM1 is necessary for targeting PBAF to inducible promoters marked by H3K14ac. We further find that PBRM1 facilitates DNA accessibility at sites bound by TGFβ1-inducible transcription factors, such as Atf3, for the induction of genes involved in migration, cell survival, and inflammation, providing evidence that PBAF is a vulnerability in late-stage metastatic cancers.
Indexed as
Breast NeoplasmsDNA-Binding ProteinsEpithelial-Mesenchymal TransitionNuclear ProteinsTranscription FactorsAnimalsCell Line, TumorCell MovementChromosomal Proteins, Non-HistoneFemaleGene Expression Regulation, NeoplasticHumansMiceNeoplasm MetastasisPromoter Regions, GeneticTransforming Growth Factor beta1Chromosomal Proteins, Non-HistoneDNA-Binding ProteinsNuclear ProteinsSWI-SNF-B chromatin-remodeling complexTranscription FactorsTransforming Growth Factor beta1
Identifiers
PMID42525774
PMCPMC13418929
What Socratic holds
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