Evidence map›Paper›PMID 42527393›Full record

ArticleNature communications2026

B cell CD19 is transferred between immune cells in mice and humans.

Jasmin Ochs, Pia Schweineberg, Jacqueline Thode, Alica Blenkle, Leila Husseini, Matthias Klein, Tobias Bopp, Patrick Schindler, Friedemann Paul, Martin S Weber

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jasmin OchsDepartment of Neurology, University Medical Center, Göttingen, Germany.
Pia SchweinebergFraunhofer Institute for Translational Medicine and Pharmacology, Göttingen, Germany.
Jacqueline ThodeInstitute of Neuropathology, University Medical Center, Göttingen, Germany.
Alica BlenkleFraunhofer Institute for Translational Medicine and Pharmacology, Göttingen, Germany.ORCID 0000-0002-4641-1863
Leila HusseiniDepartment of Neurology, University Medical Center, Göttingen, Germany.
Matthias KleinInstitute of Immunology, University Medical Center, Mainz, Germany.
Tobias BoppInstitute of Immunology, University Medical Center, Mainz, Germany.ORCID 0000-0002-3232-8065
Patrick SchindlerDepartment of Neurology with experimental Neurology, Charité, Berlin, Germany.
Friedemann PaulMax Delbrueck Center for Molecular Medicine and Charité - Universitätsmedizin Berlin, Berlin, Germany.
Martin S WeberDepartment of Neurology, University Medical Center, Göttingen, Germany. martin.weber@med.uni-goettingen.de.ORCID 0000-0001-8409-0389

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

When immune cells interact, they frequently exchange membrane-bound antigens. Our evolving understanding of these processes challenges the cellular specificity of lineage markers and therapeutic monoclonal antibodies. By using mouse and human B-T cell co-cultures, we report that CD19, an assumingly exclusive B cell marker, is transferred via trogocytosis when B cells activate T cells. In a B cell-driven model of experimental autoimmune encephalomyelitis, CD19

Indexed as

Antigens, CD19B-LymphocytesT-LymphocytesAnimalsCoculture TechniquesEncephalomyelitis, Autoimmune, ExperimentalFemaleHumansImmunoglobulin MLymphocyte ActivationMiceMice, Inbred C57BLTrogocytosisAntigens, CD19Immunoglobulin M

Identifiers

PMID42527393
PMCPMC13421502

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.