Bone- and muscle-targeted adeno-associated viral vectors enable tissue-selective vitamin D receptor knockdown in mice.

Alexandra K O'Donohue, Julian Chu, Nicholas Norris, Hsien-Yin Kao, Josephine Yu, Lucinda R Lee, Dirk Grimm, Jenny E Gunton, Aaron Schindeler

Abstract read

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In one paragraph

Article in Gene therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alexandra K O'Donohue *School of Chemical & Biomolecular Engineering, Faculty of Engineering, University of Sydney, Camperdown, NSW, Australia. alexandra.odonohue@sydney.edu.au.ORCID http://orcid.org/0000-0003-2267-3671

Julian Chu *Bioengineering and Molecular Medicine Laboratory, The Children's Hospital at Westmead and the Westmead Institute for Medical Research, Westmead, NSW, Australia.

Nicholas NorrisSydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.

Hsien-Yin KaoSchool of Chemical & Biomolecular Engineering, Faculty of Engineering, University of Sydney, Camperdown, NSW, Australia.

Josephine YuSydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.

Lucinda R LeeBioengineering and Molecular Medicine Laboratory, The Children's Hospital at Westmead and the Westmead Institute for Medical Research, Westmead, NSW, Australia.

Dirk GrimmDepartment of Infectious Diseases/Virology, Section Viral Vector Technologies, BioQuant, Medical Faculty, Faculty of Engineering Sciences, Heidelberg University, Heidelberg, Germany.

Jenny E GuntonSydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.

Aaron SchindelerSchool of Chemical & Biomolecular Engineering, Faculty of Engineering, University of Sydney, Camperdown, NSW, Australia.

Funding

National Health and Medical Research Council 2033228

6 · The paper itself

Abstract

Vitamin D receptor (VDR) regulates musculoskeletal biology, but its adult, tissue-specific roles are difficult to resolve with germline or conventional conditional knockouts. We developed recombinant adeno-associated viral vectors (rAAVs) to drive Cre recombinase selectively in bone or muscle and used them to delete Vdr postnatally in Vdr

Identifiers

PMID42527626

DOI10.1016/j.omtm.2020.09.016

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.