Evidence map›Paper›PMID 42527677›Full record

ReviewNature aging2026

Senotypes define the diverse landscape of senescent cells.

Marissa J Schafer, Nathan Basisty, Ann V Hertzel, Alexandra N Rindone, Jennifer H Elisseeff, Vidyani Suryadevara, Constantin Aliferis, Paul D Robbins, Laura J Niedernhofer, Karl N Miller and 8 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Marissa J Schafer *Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-1470-1583
Nathan Basisty *Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-6173-1139
Ann V Hertzel *Masonic Institute on the Biology of Aging and Metabolism and Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Alexandra N RindoneTranslational Therapeutics & Regenerative Engineering Center, Department Chemical and Biomolecular Engineering and Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Jennifer H ElisseeffTranslational Therapeutics & Regenerative Engineering Center, Department Chemical and Biomolecular Engineering and Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-5066-1996
Vidyani SuryadevaraDepartment of Radiology, Molecular Imaging Program at Stanford (MIPS), Stanford University, School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-4081-2989
Constantin AliferisInstitute for Health Informatics, Clinical and Translational Science Institute, Masonic Cancer Center, Data Science Program, University of Minnesota, Minneapolis, MN, USA.
Paul D RobbinsMasonic Institute on the Biology of Aging and Metabolism and Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0003-1068-7099
Laura J NiedernhoferMasonic Institute on the Biology of Aging and Metabolism and Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0002-1074-1385
Karl N MillerCancer Genome and Epigenetics Program, Sanford Burnham Prebys MDI, La Jolla, CA, USA.
Peter D AdamsCancer Genome and Epigenetics Program, Sanford Burnham Prebys MDI, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-0684-1770
Vilas MenonCenter for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-4096-8601
Hemali PhatnaniCenter for Genomics of Neurodegenerative Disease, New York Genome Center, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.
Joao F PassosDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-8765-1890
Birgit SchillingBuck Institute for Research on Aging, Novato, CA, USA.ORCID http://orcid.org/0000-0001-9907-2749
Simon MelovBuck Institute for Research on Aging, Novato, CA, USA.ORCID http://orcid.org/0000-0001-8554-2834
Nicola NerettiDepartment of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI, USA. nicola_neretti@brown.edu.ORCID http://orcid.org/0000-0002-9552-1663
Darren J BakerRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA. baker.darren@mayo.edu.ORCID http://orcid.org/0000-0001-9006-1939

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cellular senescence was initially defined in vitro as a stable cell-cycle arrest that occurs after repeated replication, but it is now recognized as a heterogeneous state shaped by cell type, species, senescence-inducing stress, tissue microenvironment and time. To organize this complexity, we propose the term 'senotype' to classify senescent cells by their inputs, molecular features and functional effects. We outline a practical framework incorporating: (1) cell identity and context; (2) inducing mechanism; (3) temporal stage; (4) multimodal molecular and structural features; and (5) physiological or pathological functions. Experimentally defined senotypes can serve as references for interpreting tissue-derived senotypes, where parameters may be incomplete. Senotypes should be anchored in combinations of core hallmarks (that is, durable cell-cycle arrest, altered secretory profiles, macromolecular or organelle damage, disrupted homeostasis) rather than single markers. Advances in single-cell, spatial, proteomic and computational methods enable rigorous senotype characterization, improving consistency and accelerating development of targeted senotherapeutics.

Identifiers

PMID42527677

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.