Evidence map›Paper›PMID 42527862›Full record

ArticleContact dermatitis2026

Tetrahydrofurfuryl Methacrylate and Isobornyl Acrylate: Possible New Sensitisers in Hearing Aid Ear Moulds.

Norbertus A Ipenburg, Anton C de Groot, Thomas Rustemeyer

Abstract read
In one paragraph

Article in Contact dermatitis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Norbertus A IpenburgDermato-Allergology and Occupational Dermatology, Amsterdam University Medical Center, Amsterdam, the Netherlands.ORCID https://orcid.org/0000-0003-0679-4131
Anton C de GrootDermato-Allergology and Occupational Dermatology, Amsterdam University Medical Center, Amsterdam, the Netherlands.ORCID https://orcid.org/0000-0002-6666-7292
Thomas RustemeyerDermato-Allergology and Occupational Dermatology, Amsterdam University Medical Center, Amsterdam, the Netherlands.ORCID https://orcid.org/0000-0001-7580-0684

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAllergic contact dermatitis from hearing aid ear moulds is infrequently reported.

objectivesTo identify cases of allergic contact dermatitis from hearing aid moulds in a cohort of patients investigated between 2022 and 2025 at Amsterdam University Medical Center. MATERIALS AND

methodsRetrospective analysis of patients referred for investigation of suspected allergic reactions to ear moulds.

resultsOf 20 patients with suspected allergic reactions to ear moulds, 8 (40%) had positive patch tests to (meth)acrylates considered to be probably relevant. All eight reacted to tetrahydrofurfuryl methacrylate, of whom five had a positive reaction to this hapten only. The other three all co-reacted to isobornyl acrylate and 1,6-hexanediol diacrylate. None had positive patch tests to hydroxyethyl methacrylate.

conclusionsThere are strong indications that tetrahydrofurfuryl methacrylate and isobornyl acrylate are relevant contact allergens present in hearing aid ear moulds. Hydroxyethyl methacrylate did not identify a single case of contact allergy to these materials.

Indexed as

AcrylatesAllergensCamphanesDermatitis, Allergic ContactHearing AidsMethacrylatesAdultAgedFemaleHumansMaleMiddle AgedPatch TestsRetrospective StudiesAcrylatesAllergensCamphanesisobornyl acrylateMethacrylates1,6‐hexanediol diacrylateacrylatesallergic contact dermatitiscontact allergyear mouldshearing aidisobornyl acrylatemethacrylatestetrahydrofurfuryl methacrylate

Identifiers

PMID42527862
PMCPMC13648303

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.