ArticleAdvanced healthcare materials2026
Hyaluronic Acid-Based Injectable Dual-Network Hydrogel for 6'-Sialyllactose Mimetic Peptide Delivery and Microenvironment Reconstruction in Brachial Plexus Root Avulsion.
Fubing Xiao, Ying Ding, Cong Ning, Yu Peng, Wenyi Li, Zijian Xiao, Heng Wu, Shuangxi Chen
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In one paragraphArticle in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
8 authors.
Fubing XiaoHunan Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, Hengyang Medical School, University of South China, Hengyang, China.ORCID https://orcid.org/0000-0003-1559-6831 Ying DingHunan Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, Hengyang Medical School, University of South China, Hengyang, China.
Cong NingHunan Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, Hengyang Medical School, University of South China, Hengyang, China.
Yu PengDepartment of Neurology, Multi-Omics Research Center for Brain Disorders, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Wenyi LiDepartment of Neurology, Multi-Omics Research Center for Brain Disorders, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Zijian XiaoDepartment of Neurology, Multi-Omics Research Center for Brain Disorders, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.ORCID https://orcid.org/0000-0001-5137-9549 Heng WuDepartment of Neurology, Multi-Omics Research Center for Brain Disorders, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Shuangxi ChenDepartment of Neurology, Multi-Omics Research Center for Brain Disorders, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.ORCID https://orcid.org/0000-0001-7711-9171 Funding
Hunan Provincial Natural Science Foundation of China 2025JJ90149Major scientific research project of national clinical key specialties 20230277National Natural Science Foundation of China 82301581University of South China Clinical Research 4310 Program 20224310NHYCG06
6 · The paper itselfAbstract
Brachial plexus root avulsion (BPRA) results in extensive motor neurons (MNs) loss, muscle atrophy, and irreversible motor dysfunction. Current surgical strategies with reimplantation fail to promote the motor recovery often leading to poor clinical outcomes, because of the too slow re-growth of the axons of MNs to re-innervate the target muscles before atrophy happens. To reconstruct the neuroprotective microenvironment to reduce the MNs death following BPRA, we developed an injectable dual-network HGα composite hydrogel encapsulating a 6'-sialyllactose (6'-SL) mimetic peptide. The HGα hydrogel was formed via Zn
Indexed as
Brachial PlexusHyaluronic AcidHydrogelsLactosePeptidesAnimalsMaleMotor NeuronsNerve RegenerationNeuroprotective AgentsRatsRats, Sprague-DawleyHyaluronic AcidHydrogelsLactoseNeuroprotective AgentsPeptides6′‐sialyllactosemimetic peptidebrachial plexus root avulsioninjectable hydrogelmicroenvironment reconstructionmotor function recovery
Identifiers
PMID42528122
PMCPMC13507558
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