Evidence map›Paper›PMID 42528512›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Scaling ECG Foundation Models and Identifying a Threshold for Effective Representation Learning.

Raghav Sriram, Ivan Nenadic, Elan Shahrabani, Sascha N Goonewardena, Shanshan Yao, Brennen Farrell, Zak Loring, Venkatesh L Murthy

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Raghav SriramLampe Joint Department of Biomedical Engineering, North Carolina State University, Raleigh, NC.
Ivan NenadicDivision of Cardiology, Department of Medicine, Northwestern University, Feinberg School of Medicine Chicago, Illinois, United States.
Elan ShahrabaniDepartment of Internal Medicine, University of California in Los Angeles, Los Angeles, California, United States.
Sascha N GoonewardenaDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, United States.
Shanshan YaoDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, United States.
Brennen FarrellDepartment of Computer Science, North Carolina State University, Raleigh, North Carolina, United States.
Zak LoringDuke Heart Center, Duke University Hospital, Durham, North Carolina, United States.
Venkatesh L MurthyDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, United States.ORCID 0000-0002-7901-1321

Funding

Metabolic architecture of insulin action in Southwest American IndiansU01DK123013 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MURTHY, VENKATESH LOCHARLA, SHAH, RAVI · 2020 to 2025
$2.4M
NIDDK NIH HHS U01 DK123013Wellcome Trust
6 · The paper itself

Abstract

We conducted a scaling evaluation of unlabeled pretraining for electrocardiogram foundation model performance. One-dimensional vision transformer (1D-ViT) masked autoencoders were pretrained across increasing ECG volumes and fine-tuned for rhythm, morphology, diagnostic, and structural heart disease tasks. Models pretrained at ≤400,000 ECGs failed to consistently exceed controls without self-supervised pre-training, whereas 600,000-800,000 ECGs improved AUROC across tasks, suggesting a minimum threshold for effective ECG representation learning.

Identifiers

PMID42528512
PMCPMC13409230

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.