ArticleFrontiers in cellular and infection microbiology2026
A retrospective analysis of pathogen distribution and antimicrobial resistance trends of bacteria in a tertiary hospital in China, 2021-2025.
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Antimicrobial resistance (AMR) poses a significant global health threat, with multidrug-resistant organisms (MDROs) increasingly contributing to healthcare-associated infections (HAIs). Understanding local pathogen distribution and resistance trends is essential for guiding empirical therapy and infection control strategies. This study aims to analyze the pathogen distribution and AMR trends of bacteria in a tertiary hospital in South China from 2021 to 2025. Methods: A retrospective analysis was conducted on bacterial isolates collected from a tertiary hospital in Guangzhou, China, from 2021 to 2025. Bacterial identification and antimicrobial susceptibility testing were performed using the VITEK 2 automated system and the Kirby-Bauer disk diffusion method, with results interpreted according to CLSI guidelines. Annual data analysis was conducted using WHONET 5.6 software. Antimicrobial consumption was expressed as defined daily doses (DDD) per 1,000 patient-days, and incidence of HAIs caused by MDROs was calculated as cases per 1,000 patient-days. Results: A total of 25,326 non-duplicate bacterial isolates were analyzed. Gram-negative bacteria predominated throughout the study period, with Conclusions: This study reveals a persistently high burden of MDROs in a South China tertiary hospital, particularly among Gram-negative pathogens. Despite increasing antimicrobial consumption, enhanced IPC measures, including active surveillance and improved contact isolation compliance, effectively reduced HAIs-MDROs incidence. These findings underscore the critical importance of integrated antimicrobial stewardship and infection control strategies in combating AMR.
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