Evidence map›Paper›PMID 42528714›Full record

ArticleFrontiers in immunology2026

Identification, characterization, and expansion of innate lymphoid cells derived from canine peripheral blood mononuclear cells.

Yeganeh Mehrani, Lily Chan, Charly McKenna, Mikaela Eng-Toogood, Fernando de Paula Freitas, Emma Vanderboon, J Paul Woods, Byram W Bridle, Khalil Karimi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yeganeh MehraniDepartment of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.
Lily ChanDepartment of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.
Charly McKennaDepartment of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.
Mikaela Eng-ToogoodDepartment of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.
Fernando de Paula FreitasDepartment of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.
Emma VanderboonDepartment of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.
J Paul WoodsDepartment of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.
Byram W BridleDepartment of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.
Khalil KarimiDepartment of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Innate lymphoid cells (ILCs), a family of innate immune cells of lymphoid origin, serve as first responders to tissue damage and inflammation. They play a crucial role in defending mammals against tumor growth. ILCs can migrate between organs, move within tissues, and replenish from the blood during inflammation. Although much is known about ILCs in humans and mice, their properties in dogs are still largely unclear. To characterize canine ILCs, peripheral blood mononuclear cells (PBMCs) were isolated and cultured to expand ILCs. PBMCs were stimulated with recombinant human interleukin-2 (rhIL-2) and recombinant canine interleukin-7 (rcIL-7) for ILC1s expansion, rcIL-33 for ILC2s, or rh/rcIL-23 for ILC3s. Flow cytometry identified ILCs in PBMCs and cultures. We demonstrated that fresh PBMCs contained distinct populations of ILC1s, ILC2s, and ILC3s, characterized by the expression of cell surface markers (Lin

Indexed as

Immunity, InnateLeukocytes, MononuclearLymphocytesAnimalsCells, CulturedDogsFlow CytometryHumansImmunophenotypingcanine immunologycanine innate lymphoid cellscomparative immunologyflow cytometryperipheral blood mononuclear cellstranscription factors

Identifiers

PMID42528714
PMCPMC13414975

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.