ArticleFrontiers in microbiology2026
Epidemiology, pathogen spectrum, and antimicrobial resistance of infections in burn patients stratified by total body surface area: a bicenter study with evaluation of targeted next-generation sequencing.
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Bloodstream Infection After Major Burn Surgery in Relation to Preoperative Glycemic Gap Among Patients Without Diabetes: A Retrospective Cohort Study.International journal of molecular sciences · 2026Article
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Authors and funding
5 authors.
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Abstract
Background: Infection remains a leading cause of morbidity and mortality in burn patients, particularly in those with extensive injuries. However, comprehensive analyses integrating pathogen distribution, antimicrobial resistance, and advanced molecular diagnostics across burn severity remain limited. Methods: We retrospectively analyzed 814 burn patients with infections admitted to two tertiary burn centers in southern China between 2020 and 2024, stratified by total body surface area (TBSA). Pathogen distribution, antimicrobial resistance patterns, complications, hospitalization costs, and length of stay were evaluated. In addition, 40 clinical specimens were prospectively analyzed using both conventional culture and targeted next-generation sequencing (t-NGS). Results: Among 814 infected burn patients stratified by TBSA (<10%, Conclusion: Burn severity is strongly associated with pathogen spectrum and antimicrobial resistance, underscoring the need for severity-stratified management strategies in burn care. In this pilot comparison, t-NGS showed a higher positivity rate than conventional culture and may serve as an adjunct diagnostic method. However, its clinical interpretation must be integrated with phenotypic data given the potential for colonization or genotypic-phenotypic discordance.
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