SynthesisFrontiers in microbiology2026
Diversity and taxonomic differences in the oral microbiota of stroke patients: a systematic review and meta-analysis.
Synthesis in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
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Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: In recent years, a growing body of evidence suggests that stroke may be associated with an imbalance in the oral microbiome. To further elucidate this potential link, this study aims to systematically compare differences in the oral microbiome between stroke patients and healthy individuals. Objective: To systematically evaluate the differences in oral microbiota diversity and taxonomic composition between stroke patients and healthy controls. Method: From the date each database was established up to 20 February 2026, we conducted searches in CNKI, Wanfang, PubMed, Embase, SinoMed, Web of Science, the Cochrane Library and grey literature databases, with the aim of identifying studies reporting on the oral microbiota of stroke patients and healthy individuals. The Newcastle-Ottawa Scale (NOS) was used to assess the risk of bias in the included studies, and meta-analysis was performed using RevMan 5.4 software. The pooled effect size was calculated as the standardized mean difference (SMD) and a parallel Z-test was conducted; heterogeneity was assessed using Cochran's Q test and the I Result: This meta-analysis of 11 studies (746 stroke patients, 552 controls) showed upward trends in Observed species (SMD = 0.39, 95% CI: 0.05-0.72, I Conclusion: The oral microbiota of stroke patients exhibits characteristic changes, which may provide preliminary clues for understanding post-stroke oral microbial alterations and offer a theoretical basis for oral care, but require validation in prospective studies. Systematic review registration: Unique Identifier: CRD420251235256, https://www.crd.york.ac.uk/PROSPERO/view/CRD420251235256.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.