Evidence map›Paper›PMID 42529208›Full record

ArticleFrontiers in microbiology2026

The forehead and glabella show pronounced

Wenjing Zha, Ke Li, Yitao Qian, Lechen Zhao, Szeman Cheung, Jianhua Huang, Fei Miao, Jie Shen, Yiwu Yu, Xinran Hu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Wenjing Zha *Department of Dermatology, Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai Institute of Geriatric Medicine, Huadong Hospital, Fudan University, Shanghai, China.
Ke Li *Department of Dermatology, Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai Institute of Geriatric Medicine, Huadong Hospital, Fudan University, Shanghai, China.
Yitao Qian *Department of Dermatology, Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai Institute of Geriatric Medicine, Huadong Hospital, Fudan University, Shanghai, China.
Lechen ZhaoFudan University, Shanghai, China.
Szeman CheungDepartment of Dermatology, Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai Institute of Geriatric Medicine, Huadong Hospital, Fudan University, Shanghai, China.
Jianhua HuangDepartment of Dermatology, Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai Institute of Geriatric Medicine, Huadong Hospital, Fudan University, Shanghai, China.
Fei MiaoDepartment of Dermatology, Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai Institute of Geriatric Medicine, Huadong Hospital, Fudan University, Shanghai, China.
Jie ShenDepartment of Dermatology, Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai Institute of Geriatric Medicine, Huadong Hospital, Fudan University, Shanghai, China.
Yiwu YuDepartment of Dermatology, Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai Institute of Geriatric Medicine, Huadong Hospital, Fudan University, Shanghai, China.
Xinran HuFudan University, Shanghai, China.
Hongwei WangDepartment of Dermatology, Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai Institute of Geriatric Medicine, Huadong Hospital, Fudan University, Shanghai, China.
Ting LyuDepartment of Dermatology, Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai Institute of Geriatric Medicine, Huadong Hospital, Fudan University, Shanghai, China.
Lei ShiDepartment of Dermatology, Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai Institute of Geriatric Medicine, Huadong Hospital, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Acne vulgaris is a prevalent chronic inflammatory skin disease, and Cutibacterium overproliferation is a core pathogenic factor, yet findings remain controversial, partly due to single anatomical area sampling bias. Methods: We conducted a crosssectional study with anatomically paired sampling across multiple facial anatomical areas in 85 subjects (30 healthy subjects, 55 acne subjects), analyzing 763 samples from 6 facial anatomical areas for 16S rRNA V4 region sequencing and microbial community analysis. Results: At the whole-face level, acne subjects had a significantly higher relative abundance of Cutibacterium and Staphylococcus compared with healthy subjects. Critically, Cutibacterium enrichment was highly dependent on facial anatomical areas: only the forehead and glabella showed significant intergroup differences, with the forehead showing a 127% higher median relative abundance (adjusted Discussion: This study demonstrates the facial anatomical area specificity of Cutibacterium enrichment, identifies the forehead and glabella as the areas with pronounced relative abundance differences between acne and healthy groups.

Indexed as

16S rRNA gene sequencingacne vulgarisCutibacteriumfacial skin microbiomeregional heterogeneity

Identifiers

PMID42529208
PMCPMC13416356

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.