Evidence map›Paper›PMID 42529269›Full record

ArticleiMeta2026

Bazi Bushen Capsule restores fertility by targeting mitochondrial health in aging endometrium.

Shangqi Li, Feng Deng, Hongjuan Niu, Meng Li, Zeyang Lin, Jiayi Ma, Yue Wang, Yueqi Leng, Yunlong Hou, Wenwen Cui and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iMeta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Shangqi LiState Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology Peking University Third Hospital Beijing China.
Feng DengState Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology Peking University Third Hospital Beijing China.
Hongjuan NiuState Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology Peking University Third Hospital Beijing China.
Meng LiState Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology Peking University Third Hospital Beijing China.ORCID https://orcid.org/0000-0003-2195-5220
Zeyang LinState Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology Peking University Third Hospital Beijing China.
Jiayi MaState Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology Peking University Third Hospital Beijing China.
Yue WangState Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology Peking University Third Hospital Beijing China.
Yueqi LengState Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology Peking University Third Hospital Beijing China.
Yunlong HouState Key Laboratory for Innovation and Transformation of Luobing Theory; Key Laboratory of State Administration of TCM (Cardio-Cerebral Vessel Collateral Disease); Shijiazhuang Yiling Pharmaceutical Co., Ltd., New Drug Evaluation Center Shijiazhuang China.
Wenwen CuiState Key Laboratory for Innovation and Transformation of Luobing Theory; Key Laboratory of State Administration of TCM (Cardio-Cerebral Vessel Collateral Disease); Shijiazhuang Yiling Pharmaceutical Co., Ltd., New Drug Evaluation Center Shijiazhuang China.
Yang YuState Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology Peking University Third Hospital Beijing China.
Heng PanState Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology Peking University Third Hospital Beijing China.
Ping ZhouState Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology Peking University Third Hospital Beijing China.ORCID https://orcid.org/0000-0002-8183-7747
Rong LiState Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology Peking University Third Hospital Beijing China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Age-related decline in endometrial function is a major cause of fertility issues in women, but effective treatments are lacking. This study aimed to investigate the impact of Bazi Bushen Capsule (BZBS) on endometrial aging and its underlying mechanisms. Using naturally aged mice and d-galactose-induced senescent human endometrial stromal cell lines, along with primary human endometrial stromal cells, we explored the effects of BZBS through single-cell RNA sequencing, transcriptome analysis, network pharmacology, and molecular dynamics simulations. Our results showed that BZBS improved endometrial receptivity, and decidualization by activating the AMPK-SIRT3 pathway. The key bioactive components of BZBS were identified as ginsenosides Rb1, Rb2, Rg5, and luteolin. Specifically, luteolin restored mitochondrial homeostasis by regulating PINK1/Parkin-mediated mitophagy and inhibiting Drp1. These findings suggested that BZBS effectively restored endometrial function and offered a promising therapeutic approach to counteract age-related endometrial dysfunction, potentially improving fertility in women of advanced maternal age.

Indexed as

AMPKBazi Bushen Capsuleendometrial agingluteolinmitochondria

Identifiers

PMID42529269
PMCPMC13416912

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.