ArticleFrontiers in sports and active living2026
Physical activity, genetic predisposition and the risk of rheumatoid arthritis: a prospective cohort study.
Article in Frontiers in sports and active living, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Physical activities have consistently been associated with rheumatoid arthritis risk. However, there is limited evidence regarding their associations according to different genetic susceptibility to the disease, and it remains poorly understood whether systemic inflammation and lipids may mediate this association. Methods: To investigate the association between physical activity and risk of rheumatoid arthritis, a multivariable Cox regression was performed using data from 351,857 participants in UK Biobank cohort. Additionally, we assessed the interaction of physical activity with polygenic risk score (PRS) for rheumatoid arthritis. We further estimated the percentage of total association between physical activity and rheumatoid arthritis that is mediated by C-reactive protein (CRP) and lipids. Results: A lower risk of rheumatoid arthritis was associated with the moderate and high level of physical activity (HR = 0.77, 95%CI = 0.70-0.84 and HR = 0.82, 95%CI = 0.75-0.89, respectively), and this association was stronger with five year after baseline. Separated by intensity of physical activity, only vigorous activity was associated with reduced risk of rheumatoid arthritis. A significant interaction was observed between physical activity and PRS for rheumatoid arthritis, indicating stronger association in those with low or medium genetic predisposition to rheumatoid arthritis. Furthermore, BMI and CRP was found to mediate 33.73% and 32.89% of the associations between physical activity and rheumatoid arthritis, while high-density lipoprotein (HDL) mediated 15.61% of the association. Conclusion: We observed an inverse association between physical activity and risk of rheumatoid arthritis in UK biobank, which was stronger in those with low or medium PRS. BMI, CRP and HDL may be key intermediates in the association, suggesting them as potential monitoring biomarker for physical activity intervention to prevent rheumatoid arthritis.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.