ArticleChemical science2026
A dual-lock strategy for tumor-specific pyroptosis activation plus gas synergism.
Xiaosheng Liu, Haidong Li, Wen Li, Zhihan Guo, Xiao Zhou, Jeongyeon Hong, Yifu Hao, Yichu Yu, Shuang Zeng, Jingyun Wang and 2 more
Abstract read
In one paragraphArticle in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
12 authors.
Xiaosheng LiuState Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, Dalian University of Technology 2 Linggong Road, Hi-tech Zone Dalian 116024 China lihd@dlut.edu.cn zengshuang@dlut.edu.cn wangjingyun67@dlut.edu.cn.
Haidong LiState Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, Dalian University of Technology 2 Linggong Road, Hi-tech Zone Dalian 116024 China lihd@dlut.edu.cn zengshuang@dlut.edu.cn wangjingyun67@dlut.edu.cn.ORCID https://orcid.org/0000-0002-2721-0337 Wen LiMOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology 2 Linggong Road, Hi-tech Zone Dalian 116024 China.
Zhihan GuoMOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology 2 Linggong Road, Hi-tech Zone Dalian 116024 China.
Xiao ZhouState Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, Dalian University of Technology 2 Linggong Road, Hi-tech Zone Dalian 116024 China lihd@dlut.edu.cn zengshuang@dlut.edu.cn wangjingyun67@dlut.edu.cn.
Jeongyeon HongDepartment of Chemistry and Nanoscience, Ewha Womans University Seoul 03760 Korea jyoon@ewha.ac.kr.
Yifu HaoMOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology 2 Linggong Road, Hi-tech Zone Dalian 116024 China.
Yichu YuMOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology 2 Linggong Road, Hi-tech Zone Dalian 116024 China.
Shuang ZengState Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, Dalian University of Technology 2 Linggong Road, Hi-tech Zone Dalian 116024 China lihd@dlut.edu.cn zengshuang@dlut.edu.cn wangjingyun67@dlut.edu.cn.
Jingyun WangState Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, Dalian University of Technology 2 Linggong Road, Hi-tech Zone Dalian 116024 China lihd@dlut.edu.cn zengshuang@dlut.edu.cn wangjingyun67@dlut.edu.cn.ORCID https://orcid.org/0000-0001-6835-2123 Xiaojun PengState Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, Dalian University of Technology 2 Linggong Road, Hi-tech Zone Dalian 116024 China lihd@dlut.edu.cn zengshuang@dlut.edu.cn wangjingyun67@dlut.edu.cn.ORCID https://orcid.org/0000-0002-8806-322X Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Pyroptosis, a canonical type of immunogenic cell death (ICD), has recently garnered extensive attention and become a highly promising strategy to enhance the efficacy of tumor immunotherapy. Unfortunately, current pyroptosis inducers face critical limitations in clinical practice, stemming from poor tumor selectivity, severe off-target effects, acquired resistance, and inadequate efficacy. Therefore, the precise induction of tumor cell pyroptosis is crucial for cancer immunotherapy, especially for the safe treatment of tumors. Herein, we designed and developed a small-molecule pyroptosis inducer (Cy-DNBS) synergistically activated by intratumoral overexpressed glutathione (GSH) and near-infrared (NIR) light. Upon GSH-triggered activation in tumors, Cy-DNBS generates fluorescence/photoacoustic (FL/PA) multimodal signals, owing to the suppression of photoinduced electron transfer (PET), and can subsequently produce large amounts of reactive oxygen species (ROS) through a photodynamic process. Meanwhile, SO
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PMID42529565
PMCPMC13417599
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