Evidence map›Paper›PMID 42529880›Full record

ReviewJournal of Zhejiang University. Science. B2026

Emerging point-of-care technologies for bacterial pathogen detection.

Wen Zhang, Yundong Hang, Sisi Zhan, Weiyao Song, Binxiao Li, Nan Chen, Min Lv

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of Zhejiang University. Science. B, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wen ZhangThe Education Ministry Key Lab of Resource Chemistry, Joint International Research Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Frontiers Science Center of Biomimetic Catalysis, and Shanghai Engineering Research Center of Green Energy Chemical Engineering, College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234, China.
Yundong HangThe Education Ministry Key Lab of Resource Chemistry, Joint International Research Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Frontiers Science Center of Biomimetic Catalysis, and Shanghai Engineering Research Center of Green Energy Chemical Engineering, College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234, China.
Sisi ZhanThe Education Ministry Key Lab of Resource Chemistry, Joint International Research Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Frontiers Science Center of Biomimetic Catalysis, and Shanghai Engineering Research Center of Green Energy Chemical Engineering, College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234, China.
Weiyao SongThe Education Ministry Key Lab of Resource Chemistry, Joint International Research Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Frontiers Science Center of Biomimetic Catalysis, and Shanghai Engineering Research Center of Green Energy Chemical Engineering, College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234, China.
Binxiao LiThe Education Ministry Key Lab of Resource Chemistry, Joint International Research Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Frontiers Science Center of Biomimetic Catalysis, and Shanghai Engineering Research Center of Green Energy Chemical Engineering, College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234, China.
Nan ChenThe Education Ministry Key Lab of Resource Chemistry, Joint International Research Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Frontiers Science Center of Biomimetic Catalysis, and Shanghai Engineering Research Center of Green Energy Chemical Engineering, College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234, China. lvmin@shnu.edu.cn, nchen@shnu.edu.cn.
Min LvThe Education Ministry Key Lab of Resource Chemistry, Joint International Research Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Frontiers Science Center of Biomimetic Catalysis, and Shanghai Engineering Research Center of Green Energy Chemical Engineering, College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234, China. lvmin@shnu.edu.cn.

Funding

the National Natural Science Foundation of China 32371439 and 22404026the Natural Science Foundation of Shanghai 24ZR1455600 and 24ZR1455900
6 · The paper itself

Abstract

Bacterial infections remain a significant threat to public health worldwide, driving an urgent need for rapid, accurate, and field-deployable diagnostic techniques. Point-of-care testing (POCT) has emerged as a transformative strategy, providing timely detection, operational simplicity, and portability. Recent studies have aimed at enhancing sensitivity, specificity, multiplexing capability, and automation through the integration of molecular diagnostics with microfluidics and lab-on-chip technologies, alongside the development of low-cost, portable devices equipped with smartphone-based readout and cloud connectivity for real-time surveillance in resource-limited settings. Nonetheless, evidence-based frameworks for selecting optimal detection targets-such as genomic sequences, conserved protein epitopes, or viable whole cells-and matching them to appropriate POCT modalities remain notably underrepresented in the literature. This review systematically summarizes recent advances in POCT strategies for bacterial detection, categorized according to three major types of detection targets, including cellular phenotypic characteristics, surface antigens, and nucleic acids. We discuss the principles, advantages, limitations, and representative applications of key POCT platforms, which include microscopy-based visualization, immunoassays, isothermal amplification, clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein (Cas) systems, and microfluidic biosensors. Critical challenges, such as sample pretreatment, detection sensitivity, and operational simplicity, have been partially addressed through recent innovations. Finally, we outline the main future research directions focused on the development of integrated, automated, and intelligent POCT systems for clinical deployment.

Indexed as

BacteriaBacterial InfectionsPoint-of-Care SystemsPoint-of-Care TestingCRISPR-Cas SystemsHumansImmunoassayNucleic Acid Amplification TechniquesRapid Diagnostic TestsBacterial detectionClustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein (Cas) system (CRISPR-Cas)ImmunoassayMicrofluidicNucleic acid amplificationPoint-of-care testing (POCT)

Identifiers

PMID42529880
PMCPMC13420505

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.