ArticleThe European journal of neuroscience2026
Serum Molecular Fingerprints of Oxidative Stress Underlying Neurocognitive and Motor Dysfunction in Pesticide-Exposed Populations.
Article in The European journal of neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Serum Molecular Fingerprints of Oxidative Stress Underlying Neurocognitive and Motor Dysfunction in Pesticide-Exposed Populations.The European journal of neuroscience · 2026Article
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Authors and funding
7 authors.
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Abstract
We investigated the relationship between chronic pesticide exposure, oxidative stress, and neurocognitive alterations in rural populations of Celendín, Cajamarca, Peru. A total of 101 adults (18-86 years) were evaluated through neuropsychological (NEUROPSI) and neuromotor assessments, serum oxidative stress biomarkers, and Fourier-transform infrared spectroscopy (FT-IR) of serum samples. Biomarkers analyzed included superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), total glutathione, lipid peroxidation (malondialdehyde), biopyrrins (BPn), and 8-hydroxy-2'-deoxyguanosine (8-OHdG). Statistical comparisons (Mann-Whitney U) and multivariate analyses (PCA, PLS-DA) were performed to identify biochemical and spectral alterations. Pesticide users exhibited a significantly higher frequency of attention deficit (OR = 4.4, 95% CI = 1.2-15.9) and elevated serum 8-OHdG levels (p = 0.042), indicating increased oxidative DNA damage. While antioxidant enzyme activities did not differ significantly, higher malondialdehyde and BPn levels suggested enhanced lipid and bilirubin oxidation. FT-IR analysis revealed distinct spectral signatures in individuals with moderate cognitive impairment, impaired left-hand motor control, and executive dysfunction (calculation). Significant bands appeared in the 440-493 cm
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