ReviewGenome biology and evolution2026
Emergence Biases in Molecular Evolution.
Review in Genome biology and evolution, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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2 authors.
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Abstract
Biases in molecular evolution can significantly influence evolutionary trajectories. They have been described in a variety of contexts, such as development and mutation, but not for the emergence of new and observable molecular activities. Here, we formalize the term "emergence bias" as the molecular predisposition that, upon mutation, biases a genetic sequence toward or against manifesting new or latent functions or phenotypes. These biases have been observed in previous studies for the emergence of promoters, enhancers, and de novo proteins, but have never been formally characterized as such. In this Perspective piece, we describe these studies and synthesize their findings through the prism of a unifying term, emergence bias, to provide support for this new concept and speculate on its molecular underpinnings. We believe that emergence biases may play an important role in evolution by canalizing which functions can and cannot emerge.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.