ArticleJACC. Case reports2026
ST-Segment Elevation Caused by Lung Cancer Mimicking STEMI.
Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
backgroundST-segment elevation on an electrocardiogram (ECG) is a hallmark of acute ST-segment elevation myocardial infarction (STEMI). However, thoracic malignancies can produce electrocardiographic patterns identical to acute ischemia through direct myocardial invasion or extrinsic compression, creating a significant diagnostic dilemma. CASE PRESENTATION: We present 2 patients with primary lung cancer who exhibited ECG findings strongly mimicking acute STEMI. Case 1 involves a 70-year-old man presenting with acute chest pain. His ECG demonstrated anterolateral ST-segment elevation with diffuse PR depression. Coronary angiography revealed nonobstructive disease with mildly elevated troponin. Multimodality imaging identified a hypermetabolic mass externally compressing the anterolateral myocardium. Case 2 describes an 80-year-old man presenting with dizziness and ST-segment elevation in leads V
conclusionsThese cases demonstrate that ST-segment elevation in patients with advanced malignancy may arise from myocardial tumor invasion or extrinsic compression rather than acute coronary thrombosis, underscoring the importance of careful correlation between clinical findings and multimodality cardiac imaging.
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