ReviewJournal of the International Society of Sports Nutrition2026
Delaying task failure in high-intensity exercise: a Pi-afferent-effort framework for targeted sports nutrition.
Review in Journal of the International Society of Sports Nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
backgroundTask failure during high-intensity exercise may reflect the convergence of intramuscular, neural, perceptual, and behavioral boundaries rather than the consequence of a single fatigue mechanism.
methodsThis hypothesis-generating narrative review proposes the Pi-afferent-effort model of task failure during high-intensity exercise and applies the model to targeted performance nutrition.
resultsRapid ATP turnover increases inorganic phosphate (Pi), while phosphocreatine breakdown through the creatine kinase reaction buffers ATP availability. As phosphate-linked disturbance progresses, Pi may impair crossbridge function, Ca
conclusionsFuture studies should combine metabolic, neuromuscular, perceptual, and performance outcomes to determine whether supplements reduce work-matched strain, increase tolerance of terminal strain, or both.
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