Evidence map›Paper›PMID 42530704›Full record

Observational studyEuropean journal of nutrition2026

Association between fish-related metabolites and metabolic syndrome risk factors in Japan: INTERLIPID metabolome -wide association study.

Tserenlkham Byambajav, Queenie Chan, Yukiko Okami, Aya Kadota, Naoko Miyagawa, Nagako Okuda, Hideaki Nakagawa, Kiyomi Sakata, Shigeyuki Saitoh, Akira Okayama and 11 more

Registry-linked trialAbstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in European journal of nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00005271 (INTERMAP), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00005271 completednot on this map

INTERMAP: International Population Study on Macronutrients and BP

TypeobservationalSponsorNorthwestern UniversityRan1995 to 2015Enrolled4,680ConditionsCardiovascular Diseases, Heart Diseases, Hypertension
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Tserenlkham ByambajavDepartment of Public Health, Shiga University of Medical Science, Otsu, Japan. tseren@kobepharma-u.ac.jp.ORCID http://orcid.org/0000-0001-6520-191X
Queenie ChanDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Yukiko OkamiNCD Epidemiology Research Center, Shiga University of Medical Science, Otsu, Japan.
Aya KadotaDepartment of Public Health, Shiga University of Medical Science, Otsu, Japan.
Naoko MiyagawaDepartment of Public Health, Shiga University of Medical Science, Otsu, Japan.
Nagako OkudaDepartment of Health Science, Kyoto Prefectural University, Kyoto, Japan.
Hideaki NakagawaMedical Research Institute, Kanazawa Medical University, Ishikawa, Japan.
Kiyomi SakataDepartment of Hygiene and Public Health, Iwate Medical University, Morioka, Japan.
Shigeyuki SaitohSchool of Health Sciences, Sapporo Medical University, Sapporo, Japan.
Akira OkayamaDepartment of Non-Communicable Diseases, Research Institute of Strategy for Prevention, Tokyo, Japan.
Katsushi YoshitaDepartment of Food Science and Nutrition, Osaka City University, Osaka, Japan.
Kamal MasakiKuakini Medical Center, Honolulu, HI, USA.
Chung-Ho E LauDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Timothy M EbbelsSection of Bioinformatics, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Linda Van HornFeinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Elaine HolmesSection of Nutrition, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Paul ElliottDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Jeremiah StamlerFeinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Hirotsugu UeshimaDepartment of Public Health, Shiga University of Medical Science, Otsu, Japan.
Katsuyuki MiuraDepartment of Public Health, Shiga University of Medical Science, Otsu, Japan. miura@belle.shiga-med.ac.jp.
INTERMAP/INTERLIPID Research Groups

Funding

Japan Society for the Promotion of Science 090357003Japan Society for the Promotion of Science 17H01553Japan Society for the Promotion of Science 19K24254Japan Society for the Promotion of Science 21K17306NHLBI NIH HHS R01-HL135486NHLBI NIH HHS R01-HL50490NHLBI NIH HHS R01-HL65461NHLBI NIH HHS R01-HL84228
6 · The paper itself

Abstract

backgroundPrevious findings for the association of fish intake and its related metabolites on risk of metabolic syndrome (MetS) are inconsistent and limited. The prevalence of fish and shellfish consumers are high in Japan where it contributes to one fourth of the protein intake. We aimed to investigate the relationship of fish and fish-related metabolites with MetS risk factors in a community-dwelling Japanese population.

methodsIn this cross-sectional study, 1047 Japanese men and women aged 40-59 years were included. Four in-depth multiple-pass 24-h dietary recalls, two timed 24-h urine collections, blood collection, extensive questionnaire and anthropometric measurements were collected for each participant. Urinary and serum profiles were obtained using

resultsMean fish intake was 47.0 (SD 28.8) g per 1000 kcal. Urinary trimethylamine-N-oxide (TMAO) and taurine, and serum creatine and threonine were significantly correlated with fish intake and homarine was associated with shellfish intake (p < 0.01). Significant inverse associations were found between triglycerides and total fish intake, low omega-3 fish, urinary TMAO, taurine and between urinary taurine with systolic blood pressure. Direct association between urinary TMAO and serum threonine with high-density lipoprotein cholesterol were found.

conclusionWe found several metabolites related to fish intake and risk factors of MetS in habitual fish-consuming country, Japan. When stratified by seafood type, raw and high omega-3 fish intake showed the strongest associations with urinary and serum metabolomes, while fried fish had weaker or non-significant correlations, suggesting that cooking methods may modulate the bioavailability or metabolic impact of fish nutrients. The combined panel of urinary TMAO and taurine with plasma creatine and threonine, reflecting seafood intake, was associated with a favorable lipid profile and lower blood pressure. CLINICAL TRAIL REGISTRATION: The INTERMAP study is registered as NCT00005271 at www. CLINICALTRIALS: gov .

Indexed as

DietFishesMetabolic SyndromeMetabolomeSeafoodAdultAnimalsBlood PressureCholesterol, HDLCross-Sectional StudiesFatty Acids, Omega-3FemaleHumansJapanMaleMethylaminesCholesterol, HDLFatty Acids, Omega-3MethylaminesTriglyceridestrimethyloxamineCardiovascular risk factorFish intakeMetabolic syndromeMetabolome-wide association studySerum metabolitesUrinary metabolites

Identifiers

PMID42530704

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.