ArticleLa Radiologia medica2026
Super-resolution ultrasound microscopy profiles microvasculomics of pancreatic ductal adenocarcinoma with pathological association and facilitates differential diagnosis.
Article in La Radiologia medica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo identify the microvasculomic profiles of PDAC through SR-US, study the correlation between SR-US characteristics and pathological microvascular density (pMVD), and preliminarily explore the differential diagnostic value of pancreatic SR-US. MATERIALS AND
methodsWe prospectively performed SR-US examinations for PDAC patients from August 2024 to June 2025. SR-US microvascular maps were reconstructed, and SR-US microvascular parameters were measured. pMVD was calculated, and the correlation between pMVD and SR-US characteristics was validated with Spearman correlation analysis. The differential diagnostic value of SR-US was analyzed by its capacity to differentiate PDAC and pancreatic neuroendocrine tumors (PNET), another common solid tumor of the pancreas, with the area under the curve (AUC) calculated.
resultsSeventy-two PDAC patients (median age: 64.00 years; 40 men) were enrolled for analysis, and 12 PNET patients were enrolled only for differential diagnosis. Thirty-seven (51.39%) PDAC showed a branch-type microvascular morphology. The medians of microvascular ratio, microvascular complexity, and perfusion index were 22.88% (16.74%, 27.13%), 1.60 (1.53, 1.65), and 2.93 (2.05, 3.65). PDAC patients with branch-type or dot-type microvasculature showed significantly lower pMVD than those with diffuse chaotic microvasculature (p = 0.010). pMVD was significantly correlated with microvascular ratio; microvascular complexity; mean, max, and min microvascular velocity; and perfusion index (all p < 0.05). SR-US characteristics achieved effective differential diagnosis between PDAC and PNET with the highest AUC up to 0.976 for microvascular ratio.
conclusionSR-US enables noninvasive evaluation of the microvasculomic profile of PDAC with preliminary evidence of pathological correlation and quantitative diagnostic value to differentiate PDAC from PNET.
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