ArticleThe Journal of international medical research2026
A novel nutritional index for hypertension risk and prediction: Cross-sectional, prospective, and trajectory evidence from the English Longitudinal Study of Ageing.
Article in The Journal of international medical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
ObjectiveHypertension is a common and modifiable cardiovascular risk factor. The triglyceride-total cholesterol-body weight index is a novel metabolic indicator derived from routine clinical measurements, but its association with hypertension remains unclear.MethodsThis longitudinal cohort study used data from 5,731 middle-aged and older adults from the English Longitudinal Study of Ageing, with cross-sectional, prospective, and trajectory analyses. Hypertension was defined as a mean systolic blood pressure ≥140 mmHg, a mean diastolic blood pressure ≥90 mmHg, antihypertensive medication use, or self-reported physician-diagnosed hypertension. For the prospective analysis, participants without hypertension at baseline were followed for a median of 12 years. For the trajectory analysis, repeated triglyceride-total cholesterol-body weight index measurements from previous waves were used to identify long-term triglyceride-total cholesterol-body weight index patterns and assess their associations with hypertension risk. Subgroup analyses and propensity score matching were performed to assess the robustness of the findings.ResultsIn the cross-sectional analyses, each one-unit increase in log-transformed triglyceride-total cholesterol-body weight index was associated with 43% higher odds of hypertension (adjusted odds ratio = 1.43, 95% confidence interval: 1.31-1.55). In the prospective analyses, baseline triglyceride-total cholesterol-body weight index predicted incident hypertension (adjusted hazard ratio = 1.16, 95% confidence interval: 1.05-1.28). Trajectory analyses identified low, moderate, and high triglyceride-total cholesterol-body weight index patterns, showing a graded increase in hypertension risk. Compared with the low-trajectory group, the high-triglyceride-total cholesterol-body weight index group had 69% higher odds of hypertension (adjusted odds ratio = 1.69, 95% confidence interval: 1.37-2.09, p < 0.001).ConclusionTriglyceride-total cholesterol-body weight index was independently and positively associated with the risk of hypertension and may provide a simple measure of metabolic burden relevant to early risk stratification.
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