Evidence map›Paper›PMID 42531607›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Soft Hypoxia-Adaptive Bioelectronics Integrating PEDOT:PSS/Polydopamine/Enzyme Biocomposites for Closed-Loop Therapeutics of Chronic Wounds.

Songrui Liu, Bowen Yang, Cao Qi, Zhijie Zhou, Haochen Zou, Anjum Qureshi, Xiao Zhao, Ting Li, Li Gao, Ye Tao and 7 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Songrui LiuState Key Laboratory of Flexible Electronics (LoFE) & Jiangsu Key Laboratory of Smart Biomaterials and Theranostic Technology, Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, Nanjing, P. R. China.
Bowen YangState Key Laboratory of Flexible Electronics (LoFE) & Jiangsu Key Laboratory of Smart Biomaterials and Theranostic Technology, Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, Nanjing, P. R. China.
Cao QiState Key Laboratory of Flexible Electronics (LoFE) & Jiangsu Key Laboratory of Smart Biomaterials and Theranostic Technology, Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, Nanjing, P. R. China.
Zhijie ZhouState Key Laboratory of Flexible Electronics (LoFE) & Jiangsu Key Laboratory of Smart Biomaterials and Theranostic Technology, Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, Nanjing, P. R. China.
Haochen ZouState Key Laboratory of Flexible Electronics (LoFE) & Jiangsu Key Laboratory of Smart Biomaterials and Theranostic Technology, Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, Nanjing, P. R. China.
Anjum QureshiSUNUM, Nanotechnology Research and Application Center, Sabanci University, Tuzla, Istanbul, Turkey.ORCID https://orcid.org/0000-0003-2171-8540
Xiao ZhaoState Key Laboratory of Flexible Electronics (LoFE) & Jiangsu Key Laboratory of Smart Biomaterials and Theranostic Technology, Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, Nanjing, P. R. China.
Ting LiState Key Laboratory of Flexible Electronics (LoFE) & Jiangsu Key Laboratory of Smart Biomaterials and Theranostic Technology, Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, Nanjing, P. R. China.ORCID https://orcid.org/0000-0002-0585-9266
Li GaoState Key Laboratory of Flexible Electronics (LoFE) & Jiangsu Key Laboratory of Smart Biomaterials and Theranostic Technology, Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, Nanjing, P. R. China.ORCID https://orcid.org/0000-0003-2465-5784
Ye TaoState Key Laboratory of Flexible Electronics (LoFE) & Jiangsu Key Laboratory of Smart Biomaterials and Theranostic Technology, Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, Nanjing, P. R. China.ORCID https://orcid.org/0000-0002-5080-2533
Gang SongState Key Laboratory of Flexible Electronics (LoFE) & Jiangsu Key Laboratory of Smart Biomaterials and Theranostic Technology, Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, Nanjing, P. R. China.ORCID https://orcid.org/0000-0003-2311-4097
Pingqiang CaiTranslational Mechanomedicine Lab, Medical School, Nanjing University, Nanjing, P. R. China.ORCID https://orcid.org/0000-0002-2665-5932
Zheng LiCollege of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, P. R. China.
Zhiyuan LiuShenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, P. R. China.ORCID https://orcid.org/0000-0001-9231-8195
Dianpeng QiSchool of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, P. R. China.ORCID https://orcid.org/0000-0002-8245-8183
Ting WangState Key Laboratory of Flexible Electronics (LoFE) & Jiangsu Key Laboratory of Smart Biomaterials and Theranostic Technology, Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, Nanjing, P. R. China.ORCID https://orcid.org/0000-0002-9143-7229
Lianhui WangState Key Laboratory of Flexible Electronics (LoFE) & Jiangsu Key Laboratory of Smart Biomaterials and Theranostic Technology, Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, Nanjing, P. R. China.ORCID https://orcid.org/0000-0001-9030-9172

Funding

Basic Research Program of Jiangsu BK20243057Basic Research Program of Jiangsu BK20253006Nanjing, National Natural Science Foundation of China 52372051National Natural Science Foundation of China 22405131National Natural Science Foundation of China 62288102National Natural Science Foundation of China 62301283National Natural Science Foundation of China 62571260Natural Science Foundation for Excellent Young Scholars 62322108Zhejiang Provincial Natural Science Foundation of China LR25E020001
6 · The paper itself

Abstract

Adaptive bioelectronics that autonomously adjust to environmental changes represent an emerging paradigm, enabling reliable operation across diverse conditions. Hypoxic microenvironments are prevalent across numerous pathological conditions including chronic wounds, tumors, and ischemic tissues, creating a fundamental challenge: oxygen-dependent enzymatic biosensors fail precisely when monitoring is most critical, while oxygen deficiency simultaneously impairs tissue regeneration. We present a soft wireless Hypoxia-Adaptive Sensing and Therapeutic (HAST) system that maintains reliable biosensing functionality in oxygen-deficient environments through integrated oxygen management. Using engineered poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS)/polydopamine (PDA)/enzyme biocomposites, HAST integrates multiplexed biosensing (glucose, uric acid, lactate) with dual-oxygen provision: wound exudate-triggered dissolved oxygen generation restores biosensor functionality while electrical stimulation promotes vascular regeneration for sustained tissue oxygenation. This hypoxia-adaptive design achieves about 10-fold biosensor sensitivity enhancement under oxygen-deficient conditions while promoting tissue repair. In preclinical diabetic wound models, HAST enabled accurate continuous monitoring with ∼30% accelerated wound closure, demonstrating environment-adaptive bioelectronics for precision medicine in oxygen-deficient pathological conditions.

Indexed as

adaptivehypoxiamultiplex biosensingsoft electronicswound healing

Identifiers

PMID42531607
PMCPMC13423484

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.