Evidence map›Paper›PMID 42533025›Full record

ArticleScientific reports2026

Patterns and trends of mortality in patients with arrhythmia and cerebrovascular disease in the United States: a nationwide analysis of older adults.

Mohamed Fawzi Hemida, Alaa Eldeeb, Maryam Saghir, Alyaa Ahmed Ibrahim, Sahil Jairamani, Abdullah Farahat Elbanna, Amr Ibrahim, Bassam Hegazy, Eshal Saghir, Mohamed Zabady and 6 more

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Mohamed Fawzi HemidaFaculty of Medicine, Alexandria University, Alexandria, Egypt. moody.fawzi1270@gmail.com.
Alaa EldeebFaculty of Medicine, Alexandria University, Alexandria, Egypt.
Maryam SaghirJinnah Sindh Medical University, Karachi, Pakistan.
Alyaa Ahmed IbrahimFaculty of Medicine, Alexandria University, Alexandria, Egypt.
Sahil JairamaniLiaquat University of Medical and Health Sciences, Jamshoro, Pakistan.
Abdullah Farahat ElbannaDepartment of Internal Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Amr IbrahimFaculty of Medicine, Monoufia University, Monoufia, Egypt.
Bassam HegazyFaculty of Medicine, Alexandria University, Alexandria, Egypt.
Eshal SaghirDow University of Health Sciences, Karachi, Pakistan.
Mohamed ZabadyFaculty of Medicine, Alexandria University, Alexandria, Egypt.
Walid BechibchiFaculty of Medicine, University of Constantine 3, Salah Boubnider, Constantine, Algeria.
Mostafa Mohamed Abdelmoneam ElsawyFaculty of Medicine, October 6 University, Giza, Egypt.
Mohamed AlatfawyFaculty of Medicine, Kafr Elsheikh University, Kafr El-Shaikh, Egypt.
Mohamed ElfekiHamad Medical Corporation, Doha, Qatar.
Karim Othman AbdelnaimFaculty of Medicine, Ain Shams University, Cairo, Egypt.
Mustafa Al-JarshawiNIHR Academy, National Institute for Health & Care Research, Leeds, UK. Mustafa.al-jarshawi@manchester.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Arrhythmias and cerebrovascular disease commonly coexist in older adults and are associated with increased mortality risk. However, population-level trends and demographic disparities in related deaths remain insufficiently characterized, necessitating large-scale analyses to better inform prevention, risk stratification, and healthcare planning. Data from CDC WONDER (1999-2023) identified U.S. mortality rates in adults aged (≥ 65 years) with arrhythmia (ICD-10: I47-I49) and cerebrovascular disease (ICD-10: I60-I69) among U.S. adults aged 65 and older. Age-adjusted mortality rates (AAMRs) per 100,000 were stratified by sex, race, urbanization and regions. Trends were analyzed using Joinpoint regression to estimate annual percent change (APC) and average annual percent change (AAPC). Between 1999 and 2023, a total of 733,476 deaths among older adults (≥ 65 years) were attributed to arrhythmias and cerebrovascular disease. The AAMRs exhibited an upward trend from 72.14 in 1999 to 74.62 in 2023 (AAPC: 0.055, 95% CI - 0.62 to 0.74; p 0.87) with a significant rise in AAMR from 65.51 in 2018 to 80.44 in 2021 (APC: 6.65; p 0.01). Men had higher AAMR than women during 1999-2023 with (73.97 to 81.27 vs. 70.22 to 69.2). NH White individuals had the highest AAMR in 2021 (87.43) with a total (631,483 deaths). The South recorded the most deaths (251,478) with a significant decline in AAMR from (70.36) in 2002 to (58.54) in 2008 (APC: - 2.89, 95% CI - 3.85 to - 1.92; p 0.004). Non-metropolitan areas had higher AAMR compared to metropolitan areas (73.62 vs. 64.71). For the place of death, the majority occurred in inpatient medical facilities (38.73%, 284,079 deaths). Mortality related to arrhythmias and cerebrovascular disease has increased in recent years among older adults. While women accounted for more deaths, men consistently had higher AAMRs. Higher mortality burden was also observed among NH White individuals, residents of the South, and urban populations, with most deaths occurring in inpatient medical facilities, highlighting the need for targeted interventions.

Indexed as

Arrhythmias, CardiacCerebrovascular DisordersAgedAged, 80 and overFemaleHumansMaleUnited StatesAging populationArrhythmiasCardiovascular epidemiologyCerebrovascular diseaseComorbidityDisparitiesMortality trendsStroke

Identifiers

PMID42533025
PMCPMC13421678

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.