Evidence map›Paper›PMID 42533042›Full record

ArticleCellular & molecular immunology2026

Platelet-derived serotonin epigenetically programs macrophage alternative activation to orchestrate type 2 airway inflammation.

Ru Tang, Guofang Xia, Ying Zhu, Jinhong Shen, Zhihan Liu, Song Mao, Jiayao Zhou, Yuelong Gu, Shilei Pu, Zhipeng Li and 8 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular & molecular immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Ru TangDepartment of Otolaryngology Head and Neck Surgery, Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai Sixth People's Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Guofang XiaDepartment of Cardiology, Shanghai Sixth People's Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ying ZhuDepartment of Otolaryngology Head and Neck Surgery, Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai Sixth People's Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID http://orcid.org/0009-0009-3520-5712
Jinhong ShenDepartment of Otolaryngology Head and Neck Surgery, Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai Sixth People's Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhihan LiuDepartment of Otolaryngology Head and Neck Surgery, Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai Sixth People's Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Song MaoDepartment of Otolaryngology Head and Neck Surgery, Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai Sixth People's Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jiayao ZhouDepartment of Otolaryngology Head and Neck Surgery, Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai Sixth People's Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yuelong GuDepartment of Otolaryngology Head and Neck Surgery, Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai Sixth People's Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shilei PuDepartment of Otolaryngology Head and Neck Surgery, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Zhipeng LiDepartment of Otolaryngology Head and Neck Surgery, Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai Sixth People's Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Hai LinDepartment of Otolaryngology Head and Neck Surgery, Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai Sixth People's Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Congfeng XuDepartment of Cardiology, Shanghai Sixth People's Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID http://orcid.org/0000-0002-8009-4865
Hongqing XuDepartment of Cardiovascular Medicine, Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou, China.
Feng ZhangDepartment of Respiratory and Critical Care, Quzhou Key Laboratory of Aging Biology and Longevity Medicine, Zhejiang-Germany Joint Laboratory on Lung Injury Repair and Regeneration, Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou, China.ORCID http://orcid.org/0000-0002-6751-0377
Yongxu ZhaoShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. zhaoyongxu@simm.ac.cn.
Shankai YinDepartment of Otolaryngology Head and Neck Surgery, Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai Sixth People's Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China. skyin@sjtu.edu.cn.ORCID http://orcid.org/0000-0003-3689-8599
Weitian ZhangDepartment of Otolaryngology Head and Neck Surgery, Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai Sixth People's Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China. drzhangwt@163.com.
Feng LiuDepartment of Otolaryngology Head and Neck Surgery, Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai Sixth People's Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China. liufeng@sibs.ac.cn.ORCID http://orcid.org/0000-0002-4442-7028

Funding

Ministry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology) 2021ZD020190Ministry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology) 2021ZD0201900National Natural Science Foundation of China (National Science Foundation of China) 81971240National Natural Science Foundation of China (National Science Foundation of China) 82271137
6 · The paper itself

Abstract

Type 2 inflammation (T2I) drives chronic airway diseases such as eosinophilic chronic rhinosinusitis (eCRS) and asthma, which are frequently accompanied by coagulation activation and platelet recruitment. However, whether and how these associated processes actively contribute to shaping inflammation remain largely unknown. Here, using single-cell transcriptomic profiling of human nasal polyp samples from eCRS patients with or without comorbid asthma, we identified a TGM2

Indexed as

AsthmaBlood PlateletsEpigenesis, GeneticInflammationMacrophage ActivationMacrophagesRhinosinusitisSerotoninAnimalsDisease Models, AnimalFemaleHistonesHumansMiceMice, Inbred C57BLProtein Glutamine gamma Glutamyltransferase 2HistonesProtein Glutamine gamma Glutamyltransferase 2SerotoninTGM2 protein, humanTransglutaminasesalternatively activated (M2) macrophagesplateletserotonylationTGM2type 2 inflammation

Identifiers

PMID42533042
PMCPMC13624266

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.