ArticleThe EMBO journal2026
NF-κB/RelA signaling required for CD40-induced humoral immunity depends on specific NEMO lysine residues in mice.
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Article in The EMBO journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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24 authors.
Donna Li *McArdle Laboratory for Cancer Research, Department of Oncology, Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0003-1099-6799
Shelly M Wuerzberger-Davis *McArdle Laboratory for Cancer Research, Department of Oncology, Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, USA.
Yuhong Chen *Versiti Blood Research Institute, Milwaukee, WI, USA.
Funita P PhanMcArdle Laboratory for Cancer Research, Department of Oncology, Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, USA.
Mei YuVersiti Blood Research Institute, Milwaukee, WI, USA.
Dominique N LisieroMcArdle Laboratory for Cancer Research, Department of Oncology, Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, USA.
Cynthia C AguilarDepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0009-0000-9467-517X
Thomas ClevenDepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Melba M TejeraDepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0009-0006-6090-5575
Parth KhatriMcArdle Laboratory for Cancer Research, Department of Oncology, Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0003-1998-5324
Natalie MedinaMcArdle Laboratory for Cancer Research, Department of Oncology, Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, USA.
Yu-Chia ChenMcArdle Laboratory for Cancer Research, Department of Oncology, Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0002-2404-7597
Ning WangDepartment of Microbiology, Immunology, and Molecular Genetics, and Institute for Quantitative and Computational Biosciences, University of California, Los Angeles, Los Angeles, CA, USA.
Philippos TsourkasBiostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, USA.
Irene OngBiostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, USA.
Jeffrey J BednarskiDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0001-6902-0876
Huy Q DinhMcArdle Laboratory for Cancer Research, Department of Oncology, Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0002-3307-1126
Alexander HoffmannDepartment of Microbiology, Immunology, and Molecular Genetics, and Institute for Quantitative and Computational Biosciences, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-5607-3845
Barry P SleckmanDepartment of Medicine - Hematology & Oncology, The University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.ORCID http://orcid.org/0000-0001-8295-4462
Aussie SuzukiMcArdle Laboratory for Cancer Research, Department of Oncology, Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0001-7390-5116
Avtar RoopraDepartment of Neuroscience, 5507 WIMR, University of Wisconsin-Madison, Wisconsin Institute for Medical Research, Madison, WI, USA.
Marulasiddappa SureshDepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Demin WangVersiti Blood Research Institute, Milwaukee, WI, USA. dwang@versiti.org.ORCID http://orcid.org/0000-0001-5549-3795
Shigeki MiyamotoMcArdle Laboratory for Cancer Research, Department of Oncology, Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, USA. smiyamot@wisc.edu.ORCID http://orcid.org/0000-0002-7827-3426
Funding
UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Justine Yang Bruce · 1985 to 2026
$142.6MCenter for Structural Biology of HIV RNAU54AI170660 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALICE TELESNITSKY · 2022 to 2026
$32.1MTraining in Cancer Biology Training GrantT32CA009135 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI SUGDEN, WILLIAM M. · 1985 to 2024
$10.4MThe Immunobiology of Vaccine-induced Immune Thrombotic ThrombocytopeniaP01HL167668 · NHLBI · VERSITI WISCONSIN, INC. · PI Mortimer Poncz · 2024 to 2026
$10.1MNovel Combination Adjuvant for Eliciting Systemic and Mucosal CD8 T Cell MemoryU01AI124299 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KLEIN, BRUCE STEVEN, SURESH, MARULASIDDAPPA · 2016 to 2025
$6.2MB cell responses in heparin-induced thrombocytopeniaR01HL130724 · NHLBI · VERSITI WISCONSIN, INC. · PI WANG, DEMIN · 2017 to 2024
$4.8MPLC?s in B cell biology and autoimmunityR01AI079087 · NIAID · VERSITI WISCONSIN, INC. · PI WANG, DEMIN · 2008 to 2018
$4.4MCharacterizing functional states of macrophages via their stimulus-responsesR01AI173214 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Alexander Hoffmann · 2023 to 2026
$2.8MChromosome dynamics and organizations necessary for faithful chromosome segregationR35GM147525 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Aussie Suzuki · 2022 to 2026
$2.5MImpact of Host NF-kB Signaling in Radiation TherapyR01CA246321 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI MIYAMOTO, SHIGEKI · 2021 to 2025
$1.8MMulti-color Benchtop Flow CytometerS10RR025483 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI BUSHMAN, WADE A · 2009 to 2009
$449kVaccine-Induced Mucosal T-Cell Immunity to Respiratory Viruses in Dirty MiceR21AI173757 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI SURESH, MARULASIDDAPPA · 2023 to 2024
$428kHHS | National Institutes of Health (NIH) 1S100OD018202-01HHS | National Institutes of Health (NIH) 1S10RR025483-01HHS | National Institutes of Health (NIH) F31CA186548HHS | National Institutes of Health (NIH) R01AI173214HHS | National Institutes of Health (NIH) R01CA246321HHS | National Institutes of Health (NIH) R21AI173757HHS | National Institutes of Health (NIH) R35 GM147525HHS | National Institutes of Health (NIH) T32CA009135HHS | National Institutes of Health (NIH) U54 AI170660HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL130724HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL167668HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI079087HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) U01AI124299NCI NIH HHS F31 CA186548NCI NIH HHS P30 CA014520NCI NIH HHS R01 CA246321NCI NIH HHS T32 CA009135NCRR NIH HHS S10 RR025483NHLBI NIH HHS P01 HL167668NHLBI NIH HHS R01 HL130724NIAID NIH HHS R01 AI079087NIAID NIH HHS R01 AI173214NIAID NIH HHS R21 AI173757NIAID NIH HHS U01 AI124299NIAID NIH HHS U54 AI170660NIGMS NIH HHS R35 GM147525NIH HHS S10 OD018202University of Wisconsin-Madison Carbone Cancer Center P30CA14520
Abstract
Oxidative stress and genotoxic damage activate NF-κB signaling through intracellular pathways distinct from those initiated by membrane receptors. DNA damage selectively induces post-translational modifications at lysine residues 277 and 309 of the human ubiquitin-binding protein NEMO to promote NF-κB signaling, but the physiological importance of these modifications in vivo remains unclear. Here, we show that a newly developed mouse model (NEMO
Indexed as
CD40 AntigensImmunity, HumoralIntracellular Signaling Peptides and ProteinsLysineNF-kappa BSignal TransductionTranscription Factor RelAAnimalsB-LymphocytesHumansMiceMice, Inbred C57BLUbiquitinationCD40 AntigensIntracellular Signaling Peptides and ProteinsLysineNEMO protein, mouseNF-kappa BRela protein, mouseTranscription Factor RelA
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.