Evidence map›Paper›PMID 42533112›Full record

ArticleOncogene2026

LncRMRP drives bladder cancer invasion via a lactylation-driven positive feedback circuit.

Yuting Gao, Chen Chen, Ruixin Sun, Yiwen Yao, Xueru Zhang, Wenqiang Quan, Jing Li, Ping Ji, Junlu Wu, Huarong Luo and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yuting Gao *Department of Laboratory Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID http://orcid.org/0009-0008-6161-5427
Chen Chen *Department of Laboratory Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Ruixin Sun *Department of Laboratory Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID http://orcid.org/0000-0002-2096-8946
Yiwen YaoDepartment of Laboratory Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Xueru ZhangDepartment of Laboratory Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Wenqiang QuanDepartment of Laboratory Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Jing LiDepartment of Laboratory Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Ping JiDepartment of Laboratory Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Junlu WuDepartment of Laboratory Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Huarong LuoDepartment of Urology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China. huarongluo8@sina.com.
Dong LiDepartment of Laboratory Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China. lidong@tongji.edu.cn.ORCID http://orcid.org/0000-0003-4129-2268
Zujun SunDepartment of Laboratory Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China. sunzujun@tongji.edu.cn.ORCID http://orcid.org/0000-0002-4094-9961

Funding

China Postdoctoral Science Foundation 2023M732653
6 · The paper itself

Abstract

Muscle-invasive bladder cancer (MIBC) remains highly aggressive. We identified the long non-coding RNA RMRP as significantly upregulated in MIBC. Functional studies demonstrated that RMRP promotes invasive phenotypes and glycolytic reprogramming. Mechanistically, RMRP binds pyruvate dehydrogenase complex X component (PDHX) and weakens the PDHX-dihydrolipoamide dehydrogenase (DLD) interaction, thereby impairing pyruvate dehydrogenase complex (PDC) function, reducing pyruvate dehydrogenase (PDH) activity, and shifting pyruvate metabolism toward lactate production. The resulting lactate promotes p300-dependent lactylation of insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) at K272 and K561, thereby stabilizing IGF2BP1 by reducing ubiquitin-mediated degradation. Stabilized IGF2BP1, in turn, binds to RMRP and stabilizes it. This establishes an RMRP-PDHX-lactate-IGF2BP1 positive feedback loop that continuously amplifies the invasive phenotype of MIBC. These findings reveal a novel mechanism by which RMRP promotes invasion through metabolic reprogramming and lactylation-mediated feedback, highlighting a potential therapeutic target for MIBC.

Identifiers

PMID42533112

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.