Evidence map›Paper›PMID 42533131›Full record

ArticleNature neuroscience2026

Creating true and false memories from forgotten information in Drosophila.

Wenbin Yang, Benedetta Zattera, Miguel Pavão-Delgado, Carolin Warnecke, Johanna Aurelia Schweizer, Ana Ricciuti, Büşra Çoban, Johannes Felsenberg

Abstract read
In one paragraph

Article in Nature neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wenbin Yang *Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.ORCID http://orcid.org/0000-0003-3100-5202
Benedetta Zattera *Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
Miguel Pavão-Delgado *Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
Carolin WarneckeFriedrich Miescher Institute for Biomedical Research, Basel, Switzerland.ORCID http://orcid.org/0009-0006-9674-0848
Johanna Aurelia SchweizerFriedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
Ana RicciutiFriedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
Büşra ÇobanFriedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
Johannes FelsenbergFriedrich Miescher Institute for Biomedical Research, Basel, Switzerland. johannes.felsenberg@fmi.ch.ORCID http://orcid.org/0000-0001-6006-1380

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI KEVIN R COOK, THOMAS KAUFMAN · 2014 to 2026
$13.5M
EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 950480NIH HHS P40 OD018537
6 · The paper itself

Abstract

Recovering forgotten memories is a double-edged sword. While regaining access to forgotten information can be advantageous, targeted memory recovery carries the risk of generating false memories. The neuronal processes governing true memory recovery and false memory formation remain poorly understood. Here we show in Drosophila that reminder cues recover forgotten aversive memories. Forgotten memories persist as silent memory traces in behaviorally neutral mushroom body output neurons. From this silent state, reminders recover memory expression by reinstating the original memory trace in mushroom body output neurons that guide behavior. However, manipulating reminders can distort recovery, leading to false memory formation. The effectiveness of this distortion depends on whether misleading reminder cues were present during the original training event. Both true memory recovery and false memory formation are context-dependent processes gated by separable dopaminergic pathways. Together, these findings suggest that forgotten memories can re-emerge through a reconstructive process that flexibly integrates stored information and recent experiences.

Indexed as

MemoryAnimalsAnimals, Genetically ModifiedAvoidance LearningCuesDrosophilaDrosophila ProteinsMushroom BodiesNeuronsDrosophila Proteins

Identifiers

PMID42533131
PMCPMC13533848

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.