Evidence map›Paper›PMID 42533233›Full record

ReviewCardiovascular engineering and technology2026

Functional Cardiac Biomaterials: Insights into Constructing a Vascularized Myocardial Tissue Surrogate.

Suresh Kumar Saravanan, Ramya Ramadoss, Pavithra Velmurugan, Veni Subramanyam, Balasubramanian Moovarkumudalvan

Abstract readReview
PubMed Publisher
In one paragraph

Review in Cardiovascular engineering and technology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Suresh Kumar Saravanan *Mahatma Gandhi Medical Advanced Research Institute (MGMARI), Sri Balaji Vidyapeeth (Deemed to be University), 607402, Puducherry, India. sureshkumars@mgmari.sbvu.ac.in.ORCID http://orcid.org/0000-0002-5165-3058
Ramya Ramadoss *Mahatma Gandhi Medical Advanced Research Institute (MGMARI), Sri Balaji Vidyapeeth (Deemed to be University), 607402, Puducherry, India.ORCID http://orcid.org/0000-0002-3144-4080
Pavithra VelmuruganMahatma Gandhi Medical Advanced Research Institute (MGMARI), Sri Balaji Vidyapeeth (Deemed to be University), 607402, Puducherry, India.ORCID http://orcid.org/0009-0008-1008-9770
Veni SubramanyamMahatma Gandhi Medical Advanced Research Institute (MGMARI), Sri Balaji Vidyapeeth (Deemed to be University), 607402, Puducherry, India.ORCID http://orcid.org/0000-0001-7379-4735
Balasubramanian MoovarkumudalvanMahatma Gandhi Medical Advanced Research Institute (MGMARI), Sri Balaji Vidyapeeth (Deemed to be University), 607402, Puducherry, India. bmoovarkumudalvan@gmail.com.ORCID http://orcid.org/0000-0003-1140-883X

Funding

Sri balaji vidyapeeth SBV/IRC/SEED MONEY/179/2024Sri Balaji Vidyapeeth SBV/IRC/SEED MONEY/171/2023
6 · The paper itself

Abstract

purposeMyocardial infarction is a pathological condition caused by impaired blood flow to the heart and is recognized as a leading contributor to cardiovascular diseases. The treatment options for myocardial infarction are currently limited, emphasizing the necessity to develop tissue engineering strategies. Nevertheless, scaffold-based techniques suffer from a number of limitations including issues of compatibility of biomaterials, immune rejection, and scarring. This review provides elaborates existing techniques and requirements for developing effective vascularized constructs for cardiac repair.

methodsPubMed, Scopus, Web of Science, and CrossRef databases were searched for related scientific literature on the subject according to PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews). 93 relevant articles were selected.

resultsCardiac patches, injectable scaffolds, hydrogels, cell sheets, and decellularized constructs are studied to be effective solutions for myocardial repair. Literature survey reveals that vascular integration and construct survival might been hanced by endothelial progenitor cells, prevascularization, 3D bioprinting, nanotechnology, and engineered exosomes.

conclusionsBiomimetic constructs for effective myocardial regeneration require appropriate biomaterials, growth factors, functional cells, and a stable vascular network.

Indexed as

BiomaterialMyocardial infarctionScaffoldTissue patchVascularization

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.