Evidence map›Paper›PMID 42533270›Full record

ArticleHormones (Athens, Greece)2026

GnRH pulse frequency is decoded by distinct Gα

George A Stamatiades, Iain R Thompson, Han Kyeol Kim, Rona S Carroll, Ursula B Kaiser

Abstract read
PubMed Publisher
In one paragraph

Article in Hormones (Athens, Greece), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

George A StamatiadesDivision of Endocrinology, Diabetes and Metabolism, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
Iain R ThompsonDivision of Endocrinology, Diabetes and Metabolism, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
Han Kyeol KimDivision of Endocrinology, Diabetes and Metabolism, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
Rona S CarrollDivision of Endocrinology, Diabetes and Metabolism, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
Ursula B KaiserDivision of Endocrinology, Diabetes and Metabolism, Mass General Brigham, Harvard Medical School, Boston, MA, USA. ukaiser@bwh.harvard.edu.ORCID http://orcid.org/0000-0002-8237-0704

Funding

TRAINING GRANT IN ACADEMIC ENDOCRINOLOGYT32DK007529 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI Ursula B. Kaiser, Anand Vaidya · 1986 to 2026
$6.3M
Deciphering the functional role of MKRN3 in puberty and reproductionR01HD082314 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI Ursula B. Kaiser · 2015 to 2026
$5.7M
Ferring Research Institute Ferring Research InstituteNIH HHS R01 HD082314NIH HHS R01/R37 HD019938NIH HHS T32 DK007529
6 · The paper itself

Abstract

purposePulsatile gonadotropin-releasing hormone (GnRH) secretion differentially regulates follicle-stimulating hormone β-subunit (Fshb) expression according to pulse frequency; however, the mechanisms by which pituitary gonadotropes decode GnRH pulsatility remain incompletely understood. GnRH activates both Gα

methodsMurine gonadotrope-derived LβT2 cells were transduced with lentiviral shRNA targeting Gnas (Gα

resultsGnRH induced pulse frequency-dependent signaling, with enhanced Creb phosphorylation at low pulse frequency and preferential Icer induction at high frequency. Gnas knockdown selectively attenuated Creb phosphorylation at low pulse frequency without affecting Icer expression. In contrast, Gnaq/Gna11 knockdown reduced Icer induction at high pulse frequency and markedly attenuated Erk1/2 phosphorylation and Egr1 expression at both frequencies.

conclusionGnRH pulse frequency is decoded in gonadotropes through differential engagement of G protein-dependent signaling pathways. Gα

Indexed as

FSHGonadotropinsG proteinsSignal transduction

Identifiers

PMID42533270

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.