SynthesisReviews in cardiovascular medicine2026
Insulin Resistance Indices and Subclinical Left Ventricular Systolic Dysfunction in Adults: A Systematic Review and Meta-Analysis.
Synthesis in Reviews in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors.
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Abstract
Background: Insulin resistance (IR) is a key characteristic of cardiometabolic disease and may contribute to subclinical ventricular dysfunction before the development of overt heart failure. Studies have reported heterogeneous results regarding the associations between IR indices and myocardial strain. Thus, this review synthesized the available evidence on the relationships between IR indices and subclinical left ventricular systolic dysfunction in adults. Methods: We systematically searched PubMed, Embase, Web of Science Core Collection, and the Cochrane Library from inception to 1 December 2025 for observational studies involving adults that reported associations between IR indices and speckle-tracking echocardiography-derived strain parameters. Eligible exposures included commonly used IR indices, such as the homeostatic model assessment of insulin resistance (HOMA-IR), the triglyceride-glucose (TyG) index, the metabolic score for insulin resistance (METS-IR), and lipid-based ratios. The primary outcome was global longitudinal strain (|GLS|). Right ventricular strain was summarized narratively because only one study reported this condition. Adjusted odds ratios (ORs) for subclinical LV systolic dysfunction per unit increase in an IR index and mean differences (MDs) in |GLS| between the highest and lowest IR categories were synthesized using random effects models with Hartung-Knapp adjustment. Results: Four studies reporting fully adjusted ORs per unit increase in an IR index showed a consistent positive association with subclinical LV systolic dysfunction. The pooled OR per unit increase in the IR index was 1.36 (95% confidence interval (CI): 1.20 to 1.53; I Conclusions: Higher IR indices were independently associated with lower GLS values, indicating worse subclinical LV systolic function. The association was directionally consistent across IR metrics, but the supportingevidence remains limited, prospective validation and interventional studies are needed. The PROSPERO Registration: CRD420251251563, https://www.crd.york.ac.uk/PROSPERO/view/CRD420251251563.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.