Evidence map›Paper›PMID 42534522›Full record

ArticleRegenerative biomaterials2026

Ginseng-derived exosomes loaded in fibrin gel promote retinal ganglion cell survival in glaucoma by exerting anti-inflammatory effects through modulating microglial polarization.

Dengming Zhou, Dehong Tan, Xuanqi Peng, Cailian Fang, Yongzhen Yu, Haroon Iqbal, Junfan Zhang, Lin Fu, Lewei Tang, Xiaoyu Zhou and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Dengming ZhouState Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China.
Dehong TanAier Academy of Ophthalmology, Central South University, Changsha 410083, China.
Xuanqi PengDepartment of Biochemistry and Molecular Biology, School of Medicine, Southeast University, Nanjing 210009, China.
Cailian FangSchool of Molecular Medicine, Hangzhou Institute for Advanced Study, UCAS, Hangzhou 310024, China.
Yongzhen YuState Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China.
Haroon IqbalState Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China.
Junfan ZhangState Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China.
Lin FuState Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China.
Lewei TangState Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China.
Xiaoyu ZhouAier Academy of Ophthalmology, Central South University, Changsha 410083, China.
Xinyue ZhangAier Academy of Ophthalmology, Central South University, Changsha 410083, China.
Run XiaoSchool of Molecular Medicine, Hangzhou Institute for Advanced Study, UCAS, Hangzhou 310024, China.
Wenxiang ZhuAier Academy of Ophthalmology, Central South University, Changsha 410083, China.
Ludan YueDepartment of Biochemistry and Molecular Biology, School of Medicine, Southeast University, Nanjing 210009, China.
Yuanbo LiangState Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glaucoma is the leading cause of irreversible blindness globally. Chronic neuroinflammation drives progressive retinal ganglion cell (RGC) loss independent of intraocular pressure, yet safe, sustained and precise neuroprotective modulation of the retinal inflammatory microenvironment remains a significant challenge. We developed an injectable fibrin gel delivery system loaded with ginseng-derived exosomes (GE-fibrin gel, GE-gel) to modulate microglial polarization, reduce retinal inflammation and promote RGC survival.

Indexed as

ginseng-derived exosomesglaucomahydrogelmicrogliaRGCs

Identifiers

PMID42534522
PMCPMC13420499

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.