SynthesisPeerJ2026
A systematic review on the dual roles of microRNAs in ischemic stroke: mechanisms and effects.
Synthesis in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
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Authors and funding
4 authors.
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Abstract
Background: MicroRNAs (miRNAs) regulate key pathways in ischemic stroke with both protective and detrimental effects. Understanding these dual roles is important to developing novel therapeutic strategies for cerebral ischemia. This systematic review highlights key miRNAs under investigation, the dysregulation of miRNA expression, and the overall mechanism of miRNA function after ischemic stroke. Methods: A total of 20 preclinical Results: During the onset of ischemia, there is a sudden upregulation of detrimental miRNAs, accompanied by downregulation of beneficial neuroprotective miRNAs. Beneficial miRNAs inhibited apoptosis, suppressed inflammation, reduced oxidative damage, protected the blood-brain barrier (BBB), promoted angiogenesis, and stimulated neurogenesis. Detrimental miRNAs inhibited critical neuroprotective signaling pathways, suppressed cellular defense mechanisms, promoted Reactive oxygen species (ROS) production, and accelerated ischemic injury. Some miRNAs play dual roles, promoting both apoptosis and neurogenesis. Discussion: MiRNA modulation demonstrated greater therapeutic potential when used in rationally designed combination therapies, such as two beneficial miRNAs ( Conclusion: MiRNAs play dual roles in ischemic stroke, mediating both injury and repair. Their pleiotropic actions position them as promising multi-targeted candidates for stroke therapy, provided translational barriers can be overcome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.