ArticleMacromolecules2026
Nanoscopic Characterization of the Thermal Phase Behavior of Random Poly(ethylene glycol-glycidyl methyl ether) Copolymers (rPEGs).
Article in Macromolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
7 authors.
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Abstract
PEGylationlinking of poly-(ethylene glycol) (PEG) to a nanocarrier or active pharmaceutical ingredient to achieve stealth propertiesis a key technology of nanomedicine. However, PEG has been shown to induce the formation of anti-PEG antibodies, motivating the search for alternative polymers for conjugation with nanocarriers. Recently, the concept of randomized PEG (rPEG), random copolymers of ethylene oxide and glycidyl methyl ether (GME), was introduced. These polymers are structural isomers of PEG with potential for manifold biomedical applications. To investigate their phase behavior in aqueous solution, a series of rPEGs with systematically varied monomer ratios were synthesized. Turbidimetric determination of the cloud point temperatures (
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