ArticleJournal of surgical case reports2026
Synchronous pure adrenal lipoma and clear cell renal cell carcinoma with sarcomatoid differentiation in a patient with a history of breast cancer: a case report.
Article in Journal of surgical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The finding of an adrenal mass in a patient with a history of extra-adrenal malignancy represents a diagnostic dilemma, in which metastasis is usually the primary suspicion. Pure adrenal lipomas are extremely rare benign tumors (<5% of adrenal neoplasms) that can coexist with other malignancies. We present the case of a 66-year-old female with a history of infiltrating ductal carcinoma of the breast treated in 2023. During her surveillance protocol, a computed tomography scan revealed a right renal mass and an ipsilateral adrenal lesion with fat density. Given the clinical suspicion of a second primary renal tumor and possible metastatic activity, a right radical nephrectomy was performed. Histopathological analysis confirmed a high-grade clear cell renal cell carcinoma (Grade 4, sarcomatoid features) pT1a, and a synchronous pure adrenal lipoma, definitively ruling out metastasis and myelolipoma. This case underscores the importance of an accurate radiological-pathological correlation to avoid diagnostic bias in complex oncological patients.
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