ArticleFrontiers in cardiovascular medicine2026
Molecular mechanisms of suxiao jiuxin pills in ameliorating post-acute myocardial infarction inflammatory response: a combined network pharmacology, Mendelian randomization, and experimental validation study.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: In recent years, Suxiao Jiuxin Pill (SJP) has emerged as a potential treatment for various cardiovascular diseases, the exact molecular mechanisms remain poorly characterized. Consequently, this study seeks to investigate the target genes associated with SJP's active components in AMI, as well as the underlying biological processes, utilizing network pharmacology (NP) and Mendelian randomization (MR) analysis. Methods: To unravel SJP's targets and its regulatory mechanisms against AMI, we combined NP, MR, and molecular docking strategies. A rat MI model was established by ligating the LAD coronary artery at the designated site. PCR and immunofluorescent labeling were applied to ovserve the expression of NAMPT and FOS. Results: Totally 44 DE-TGs were gained by intersecting 689 DEGs and 969 predicted target genes. Next, two key target genes, NAMPT and FOS, showing markedly upregulated expression in AMI samples. Observations showed that these genes were co-enriched in the "Leishmania Infection" and "Chemokine Signaling Pathway". Moreover, these key target genes showed robust associations with various immune cells, of which NAMPT exhibited a strong positive correlation with neutrophils (co Conclusion: This work further delivers a fresh conceptual framework for deciphering the mechanistic basis of SJP's clinical utility in AMI management.
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